NFL Odds Week 3: Last-Minute Betting Guide, Spread and Over-Under Analysis

Putting money on NFL games is a market, and like every market, timing is everything. Some underdogs have become larger underdogs while the week has gone on, while other lines are closer to toss-ups now. Others have completely flipped, like the New York Jets, who were home dogs at first but are now favorites over the struggling Philadelphia Eagles.

If you wanted to net the Jets, the opening line was for you. If you wanted the Eagles, this is the perfect time to strike.

I'll also recap my spread predictions for this week while updating the fluid lines, in case you have taken it upon yourself to wait until Sunday to give them a look. Additional information on the weather and injury reports will be provided, as some might overlook the impact that rain, wind, heat or replacement quarterbacks might have on Sunday's action.

I'll throw some over-under suggestions into the mix, as the public is rapidly overreacting on a week-to-week basis now. Take a deep breath and get ready. We're in the last week of September, and fall is flying by. Hold onto autumn while we still have the privilege to see Luke and Josh McCown play in meaningful games.

Spread Picks

Michael Conroy/Associated Press

The Line: Cincinnati @ Baltimore (-2.5)

The Pick: Cincinnati (+2.5)

The Line: Jacksonville @ New England (-13.5)

The Pick: New England (-13.5)

The Line: Pittsburgh @ St. Louis (+1.5)

The Pick: St. Louis (+1.5)

The Line: Oakland @ Cleveland (-4.5)

The Pick: Oakland (+4.5)

The Line: New Orleans @ Carolina (-3)

The Pick: Carolina (-3)

The Line: Indianapolis @ Tennessee (+5)

The Pick: Tennessee (+5)

The Line: Atlanta @ Dallas (PK)

The Pick: Atlanta (PK)

The Line: Tampa Bay @ Houston (-4)

The Pick: Houston (-4)

The Line: Philadelphia @ New York Jets (-2.5)

The Pick: Philadelphia (+2.5)

The Line: San Diego @ Minnesota (-2.5)

The Pick: San Diego (+2.5)

The Line: San Francisco @ Arizona (-6)

The Pick: Arizona (-6)

The Line: Buffalo @ Miami (-2.5)

The Pick: Miami (-2.5)

The Line: Chicago @ Seattle (-14.5)

The Pick: Chicago (+14.5)

The Line: Denver @ Detroit (+2.5)

The Pick: Denver (-2.5)

The Line: Kansas City @ Green Bay (-6.5)

The Pick: Green Bay (-6.5)

As always, you can find my spread picks on Thursdays in Bleacher Report's Ultimate Bettor's Guide.

Line Movement

Darron Cummings/Associated Press

Oakland @ Cleveland

Opened: Cleveland -4.5

Current: Cleveland -3.5

Cincinnati @ Baltimore

Opened: Baltimore -1.5

Current: Baltimore -2.5

Jacksonville @ New England

Opened: New England -14

Current: New England -13.5

Tampa Bay @ Houston

Opened: Houston -4

Current: Houston -6.5

Pittsburgh @ St. Louis

Opened: St. Louis +1.5

Current: St. Louis PK

Philadelphia @ New York Jets

Opened: Philadelphia -2.5

Current: Philadelphia +2

Indianapolis @ Tennessee

Opened: Tennessee +5

Current: Tennessee +3

San Diego @ Minnesota

Opened: Minnesota -2

Current: Minnesota -2.5

Atlanta @ Dallas

Opened: Atlanta PK

Current: Atlanta -2

New Orleans @ Carolina

Opened: Carolina -3.5

Current: Carolina -8 (Drew Brees is out)

San Francisco @ Arizona

Opened: Arizona -6

Current: Arizona -6.5

Buffalo @ Miami

Opened: Miami -2.5

Current: Miami -3

Chicago @ Seattle

Opened: Seattle -14

Current: Seattle -15

Denver @ Detroit

Opened: Detroit +2.5

Current: Detroit +3

Kansas City @ Green Bay

Opened: Green Bay -6.5

Current: New England -6.5

Lines courtesy of Odds Shark.

Over-Under Picks

Charlie Riedel/Associated Press

Pittsburgh @ St. Louis: Under 48

When the St. Louis Rams are on, they have the best defensive line on the planet and can shut teams down. People are getting overexcited about Pittsburgh's scoring total last week against a below-average San Francisco 49ers defense that was coming off a short week. They're also overreacting to Le'Veon Bell's return from suspension.

People do realize that DeAngelo Williams has rushed for more than 200 yards this season already, right? How much more can you ask from Bell?

You're thinking of Ben Roethlisberger running packaged plays in a dome, while I see the Rams putting the brakes on this whole game, trying to slow it down with a plodding ground attack. At home, St. Louis is just a different team.

Kansas City @ Green Bay: Under 49

The Kansas City Chiefs can't play from behind with Alex Smith at quarterback. He just can't make the throws when the Chiefs are down multiple scores to get them back in the game. Because of that, expect the Chiefs to try to run the ball early and often, making the game shorter in the process.

With an extended rest from Thursday Night Football, Kansas City might be able to throw some complex concepts at Green Bay's offense too. Aaron Rodgers is near unbeatable at home, but the Chiefs have stars at every level of their defense, with Dontari Poe, Justin Houston, Derrick Johnson, Tamba Hali and rookie stud Marcus Peters now stepping up as the team's top defensive back.

Philadelphia @ New York Jets: Over 45.5

The Jets defense is largely based around setting up the Cover 0 blitz. Cornerback Darrelle Revis is questionable, which means someone might have to come off the bench to play man-to-man coverage against the Philadelphia Eagles in place of him.

Here's the other thing: Chip Kelly's ideal situation would be facing one-on-one cornerbacks. People are underrating the Eagles, who just need to switch up their formation looks and go back to running a high-tempo offense to get back on track. The Jets have a short week after Monday Night Football to prepare for an adjusting Eagles team. Good luck.

Weather Reports

Stephen Brashear/Associated Press

Open Stadium

Oakland @ Cleveland

High: 73 degrees

Low: 63 degrees

Description: Mostly cloudy

Precipitation: 20 percent

Wind: SE 15 mph

Cincinnati @ Baltimore

High: 73 degrees

Low: 66 degrees

Description: Cloudy

Precipitation: 20 percent

Wind: ENE 12 mph

Jacksonville @ New England

High: 72 degrees

Low: 51 degrees

Description: Partly cloudy

Precipitation: 0 percent

Wind: SSE 8 mph 

Philadelphia @ New York Jets

High: 74 degrees

Low: 61 degrees

Description: Partly cloudy

Precipitation: 0 percent

Wind: E 8 mph

Indianapolis @ Tennessee

High: 80 degrees

Low: 62 degrees

Description: Cloudy

Precipitation: 20 percent

Wind: SE 6 mph

San Diego @ Minnesota

High: 78 degrees

Low: 62 degrees

Description: Sunny

Precipitation: 0 percent

Wind: S 14 mph

New Orleans @ Carolina

High: 72 degrees

Low: 63 degrees

Description: Showers

Precipitation: 60 percent

Wind: NNE 10 mph

Buffalo @ Miami

High: 89 degrees

Low: 77 degrees

Description: Mostly cloudy

Precipitation: 10 percent

Wind: E 8 mph

Chicago @ Seattle

High: 64 degrees

Low: 48 degrees

Description: Sunny

Precipitation: 0 percent

Wind: N 11 mph 

Kansas City @ Green Bay

High: 75 degrees

Low: 62 degrees

Description: Partly cloudy

Precipitation: 10 percent

Wind: S 11 mph

Retractable Stadium

San Francisco @ Arizona

High: 105 degrees

Low: 77 degrees

Description: Sunny

Precipitation: 0 percent

Wind: SE 7 mph

Atlanta @ Dallas

High: 91 degrees

Low: 69 degrees

Description: Mostly sunny

Precipitation: 0 percent

Wind: ENE 7 mph

Tampa Bay @ Houston

High: 81 degrees

Low: 70 degrees

Description: Showers

Precipitation: 50 percent

Wind: NE 10 mph

Dome Stadium

Denver @ Detroit

Pittsburgh @ St. Louis

All data retrieved via Weather.com's five-day forecasts.

Injury Report

Gerald Herbert/Associated Press

Drew Brees, QB, New Orleans

In what is probably the biggest injury of this season so far, Drew Brees hurt his shoulder against the Tampa Bay Buccaneers last week. While one hopes that he may not be out for long, the 36-year-old may be wearing thin. The New Orleans vs. Carolina lines has swung 4.5 points since Brees was ruled out. The Saints are in trouble.

Jay Cutler, QB, Chicago

Like Drew Brees, the injury to Jay Cutler is one of the more impactful ones in the NFL. Now, backup Jimmy Clausen must make a start in Seattle against the Seattle Seahawks, who are motivated by their 0-2 record. On top of that, the Bears' top receiver, Alshon Jeffery will miss the game to a hamstring issue. Chicago is a near three-score underdog everywhere, and for good reason.

DeMarco Murray, RB, Philadelphia

DeMarco Murray has fewer rushing yards than Marquise Lee, a sophomore receiver with the Jacksonville Jaguars, and is tied with Richard Rodgers, the Packers' starting tight end. He has a hamstring issue that will come down to a decision on Sunday, but at this point, he hasn't made much of an impact in 2015 anyway. With Ryan Mathews and Darren Sproles in the backfield, the Eagles can replace Murray if he can't go.

Tevin Coleman, RB, Atlanta

Early on in the season, one thing has become apparent: Tevin Coleman is the most talented of Atlanta's running backs. The rookie is a great fit for the Falcons' zone scheme, as he resembles a young Ryan Grant. He's going to miss the battle in Arlington, Texas, though, with a rib issue. Devonta Freeman has skills, and this could be his opportunity to show the world, and his coaching staff, what he has.

Todd Gurley, RB, St. Louis

No one knows when Todd Gurley will return to action after an ACL injury ended his final season at the University of Georgia. He's going to be a game-time decision from here on out, but the Rams desperately need a star to emerge offensively. Right now, their offense rests totally on the shoulders of Nick Foles, which is never a good sign.

Luke Kuechly, LB, Carolina

Luke Kuechly isn't 100 percent cleared from a concussion he suffered against the Jacksonville Jaguars in Week 1. Carolina's pass defense needs him, as his ability in coverage allows for shorter drops for the safeties, but against a lackluster New Orleans offense without Drew Brees, the Panthers may not need him at all. This will likely come down to a game-time decision.

Ryan Shazier, LB, Pittsburgh

Ryan Shazier was Pittsburgh's first-round pick last season and is breaking out during his second NFL campaign. He's a freak athlete, and the transitioning defense is built for undersized linebacker to fly around to the ball. He's going to miss this week against the St. Louis Rams due to a shoulder injury. How will this Steelers defense look without him? It's a big question.

Vontae Davis, CB, Indianapolis 

Everyone wants to talk about Andrew Luck's flaws thus far this season, but no one wants to admit that the Colts might have a bottom-five defense in the league. Their cornerbacks are dropping like flies, and Vontae Davis, who is probably their best defender, is the latest victim. He suffered a concussion against the New York Jets on Monday Night Football but has been cleared to play Sunday against in-division rival Tennessee.

Darrelle Revis, CB, New York Jets

The New York Jets have been able to play an aggressive style of defense, blitzing often with only man coverage behind the rush, but it's only possible because of their talented cornerbacks. Darrelle Revis, the top cornerback in the NFL, is battling a groin issue. If he's not ready on Sunday, it could affect the style of play the Jets have gone with in 2015.

Injury information courtesy of ESPN.com.