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San Francisco 49ers running back Marcus Lattimore.
To start off, here are a few injuries that are already likely going to cost a player the entire 2013 season—and in some cases, even more.
Jahvid Best, RB (Detroit Lions)
Best's story may soon become the one at which everyone points when discussing concussion management.
After suffering multiple concussions over a relatively short time period, the former University of California standout remains unable to attain neurological clearance to return to the field. His career is likely over—a heartbreaking, yet sobering, reminder of the danger of football.
Desmond Bishop, LB (Unsigned free agent)
Bishop ruptured his hamstring—also known as a grade-three strain—during the 2012 preseason. Ruptured hamstrings are not like typical, run-of-the-mill hammies, as they require surgical re-attachment of the torn tendon to the bone as well as a prolonged recovery.
An understandably slow rehab from such a devastating injury likely played a large part in Bishop's recent release from the Green Bay Packers, and as Bleacher Report's own Zach Kruse writes, his future is unfortunately anything but certain.
Victor Butler, LB (New Orleans Saints)
Butler tore his anterior cruciate ligament (ACL) last week, an injury that almost always requires between eight months to a year from which to return. Even in the best-case scenario, he likely won't take the field this season.
Melvin Ingram, LB (San Diego Chargers)
Ingram also suffered a torn ACL, but his injury occurred in May. Nevertheless, a full recovery in time to meaningfully contribute to the 2013 season would be nothing short of miraculous.
Marcus Lattimore, RB (San Francisco 49ers)
A dislocated knee infamously sidelined Lattimore last October. He could return to the field at some point during his rookie season, but 49ers fans should be prepared to not see him in action until 2014.