The 2012 NFL season has been a wild one, as many perennial contenders have fallen to cellar-dwelling underdogs over the course of the first 11 weeks of the year.
Heading into Week 12, there are a number of tilts featuring heavy favorites who could be upset by relatively mediocre teams, despite many are no longer even in contention for postseason berths.
Here's a look at some of the league's heavyweights who will suffer losses to underdogs in Week 12.
Pittsburgh at Cleveland
Though Pittsburgh's record is far better than Cleveland's, the Steelers will more than likely be playing without star quarterback Ben Roethlisberger, who, according to ESPN's Chris Mortensen and Adam Schefter, will be out for three weeks.
Assuming he's unable to play, the Steelers' offense won't be nearly as dangerous, With the Browns coming off a strong showing against the Cowboys, they'll be primed to pull off a big upset over Pittsburgh.
The Browns have struggled mightily all year long, but they'll get a feel-good victory over the Steelers in Week 12.
Prediction: Cleveland 20, Pittsburgh 17
Seattle at Miami
The Seattle Seahawks have been one of the league's biggest surprises this season, as Pete Carroll's team enters Week 12 at 6-4. They appear to be in a good position to grab a postseason berth heading into their clash with the Dolphins.
At the other end of the field, Miami has been inconsistent all year. When they've played to their potential, they've looked like a completely different team than the one that lost to Buffalo on Thursday night.
Reggie Bush will bounce back from his poor showing in Week 11 and the Dolphins will move to 3-2 at home, putting a serious dent in Seattle's postseason chances.
Prediction: Miami 27, Seattle 21
New England at New York Jets
New York's season has been an ongoing soap opera, as the 4-6 Jets have been one of the league's most inconsistent teams.
In the first meeting of the year between the Patriots and Jets, New England squeaked by New York with a 29-26 overtime victory. With Rex Ryan's squad coming off a dominant win over the Rams, the Jets will have momentum going into their Week 12 tilt at MetLife Stadium.
Mark Sanchez played some of his best football of the season against the Rams, going 15-of-20 for 178 yards and a touchdown. New England boasts one of the league's worst pass defenses and Jets will score a big upset over the perennial Super Bowl-contending Patriots in Week 12.
Prediction: New York Jets 24, New England 21