With the first game of Week 6 in the books, many fantasy football owners are trying to figure out how to replace the points they didn't get with Rashard Mendenhall. Others are trying to fill gaps left with the Chicago Bears and Jacksonville Jaguars on their bye weeks.
Owners with the following players have to be feeling pretty good about their chances this weekend, though. For those of us who have three from this list...all the better.
Owners looking to fill a hole at running back might give LaRod Stephens-Howling a look this weekend. Injuries in Arizona have made him the guy in the desert, but the offensive line didn't exactly manage to clear room for Beanie Wells or Ryan Williams.
The following runners have been amassing points, though, and should have matchups that enable them to do just that this weekend.
10. BenJarvus Green-Ellis, Cincinnati Bengals vs. Cleveland Browns
He's been notably absent in recent weeks, but Green-Ellis should have an opportunity against a lacking Browns run defense.
9. Frank Gore, San Francisco 49ers vs. New York Giants
It doesn't seem to matter what defense Gore plays. The guy just produces.
8. Marshawn Lynch, Seattle Seahawks vs. New England Patriots
Seattle needs to get a little more passing action this week, but it can't get it done without Beast Mode.
7. Alfred Morris, Washington Redskins vs. Minnesota Vikings
With questions surrounding Robert Griffin III's concussion, the Redskins need to take some of the pressure off their rookie signal-caller.
6. Jamaal Charles, Kansas City Chiefs vs. Tampa Bay Buccaneers
Charles will have a tough matchup, but the Chiefs may need to turn to him with Matt Cassel out.
5. Ray Rice, Baltimore Ravens vs. Dallas Cowboys
Ravens fans are waiting for Rice to have his breakout game of 2012. He's had a pair of 20-point fantasy days, but hasn't hit for 160 yards and a pair of scores yet.
The Cowboys present a matchup that could allow Rice to do just that. They are somewhat stout against the run, allowing just 108 yards per game, but hard-nosed runners have been able to carve out yards against Dallas.
4. Willis McGahee, Denver Broncos vs. San Diego Chargers
McGahee has been hit-and-miss this season. The Chargers can surrender yards in bunches, making this a good week for McGahee to explode.
Fantasy owners might be leery of another single-digit output, but will be disappointed if they leave McGahee's 23 points on the bench.
Besides, it is more fun to have a player going on Monday night. It feels good to snake out a win in the final 15 minutes of play.
3. Trent Richardson, Cleveland Browns vs. Cincinnati Bengals
The Browns and Bengals could turn into a good old-fashioned slugfest worthy of the AFC North.
The Browns need to keep the pressure off Brandon Weeden if they are going to pick up their first win on the season. The best way to do that is to give the ball to their star.
Weeden will get plenty of opportunities on the ground and in the passing game on Sunday.
2. Arian Foster, Houston Texans vs. Green Bay Packers
It would be too boring to pick the top rusher to have the best day. The Packers have been stout against the pass, but have surrendered some rushing yards in 2012.
The Texans likely will want to avoid turning their game into a slugfest with Aaron Rodgers. It is just a matter of time before his offense catches fire, and the best way to keep it from happening is to keep him off the field as much as possible.
Foster could pick up both of Houston's touchdowns in a 100-plus-yard effort.
1. Adrian Peterson, Minnesota Vikings vs. Washington Redskins
The Redskins look like a great run defense on paper. They are ranked 10th in yards per game, allowing just 88.
But when they give up 330 yards through the air, there isn't much of a reason to run the ball.
Christian Ponder will spread the ball around in this game. He'll go downfield, hand off to Peterson and work the ball out to AP in the flat.
Peterson is another player who hasn't had his breakout performance in 2012. I'm predicting it comes on Sunday.
Darin Pike is a writer for Bleacher Report's breaking news team and is a featured columnist who covers the NFL and Seattle Seahawks.