For the first time in this rivalry, Manning will be in a Broncos uniform as he takes on his biggest nemesis. However, the goal has not changed. With both the Patriots and Broncos looking to earn their third win of the season, the question remains if there will be another memorable prime-time game for the ages.
There have been plenty of memorable clashes between Manning and Brady, but which were the most memorable of the past decade?
Here are the five best games played between these rivals.