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1. Marshawn Lynch vs. Green Bay Packers
The Packers' pass-rush seems to be back, and better than ever after two games. Pete Carroll won't be inclined to try and throw the ball all game with his rookie running back. After gobbling up 122 yards and a touchdown against the Dallas Cowboys in Week 2, Beast Mode will have another big game against the seventh-worst run defense in the NFL.
2. Reggie Bush vs. New York Jets
The Jets aren't as good on defense as many people think, and a big reason for it is that they don't stop the run on a regular basis. So far this year, the Jets are ranked 22nd in the NFL against the run, letting opposing running backs break off 4.8 yards per carry.
Bush is going to have a monster game, because there's no way Joe Philbin will put his rookie quarterback at risk against a stingy secondary.
3. Arian Foster vs. Denver Broncos
Most weeks on the NFL schedule, Foster would head this list. He's the most reliable running back in fantasy football. He's going up against a tough defense this week, though, and his numbers will decline a bit.
4. Frank Gore vs. Minnesota Vikings
This is more about Gore and the San Francisco 49ers than it is about the Vikings having a bad run defense. The 49ers are going to feed their star running back, and it seems safe to say he'll have 100 yards and a touchdown by the end of the game.
5. Trent Richardson vs. Buffalo Bills
Richardson—not C.J. Spiller—will end up being the fantasy stud in this contest. The Cleveland Browns are going to rain on Spiller's parade, while Richardson will build on his impressive performance against the Cincinnati Bengals a week ago against the 24th-ranked run defense in the NFL.