The Lions' offensive line lacks the star power of the defensive line, although their job is much easier.
Anchored by veterans Rob Sims and Jeff Backus, it doesn't take much of a running lane for RB Jahvid Best to make a dash through the secondary.
It's going to take a monster effort to shut down this speedster, and if anyone can do it, it's San Francisco's speedy linebacker core.
So long as Justin Smith and company can dominate the line play and plug up the gaps, the 49ers linebackers are better set than most teams in the NFL to shut down the Lions' running attack.
Which leads us to the Lions' biggest threat and the 49ers' biggest weakness on defense, which is the passing game.
Look for Carlos Rogers to have a breakout game against WR Calvin Johnson if the 49ers are able to get a good pass-rush on Lions QB Matthew Stafford.
It's going to be up to Ahmad Brooks and Aldon Smith to play their best games of the year thus far to get the kind of pressure necessary.
This won't be easy considering the effort it's going to take to shut down the run game from the defensive line, and the fact that the Lions get the ball out quick and complete a lot of quick passes.
If the 49ers remain patient, and the rush gets to Stafford when the Lions do take a shot down field, then the offensive line's job for the Lions will be a lot harder than they're used to and it could get pretty ugly for the Lions for what will turn into a marathon of a game.