In a 16-game schedule, it is inevitable that every NFL fantasy owner will be faced with some injuries throughout the season. Some injuries are the one-week variety, while others are more like Peyton Manning, where you know that they will be gone for at least a couple weeks, but you don't really know how many more weeks after that he will be out of commission.
Some injuries fantasy owners are able to absorb because they were able to handcuff a backup player to the starter, so they haven't lost that much in the grand scheme of things. But there are some players that are just so vital to your team that any week they are missing, your team is fighting an uphill battle.
Today we are covering the Top 12 injuries that will have an impact on your Week 5 fantasy roster. If the player in question has already been placed on season-ending I.R. since Week 3, there is no reason to include them in this list, since that is old news and would be redundant. This article is to bring you up to speed on the injury activity from Week 4 to make sure you are up to speed. We went to publication prior to the Monday Football Game of Week 4 between Tampa Bay and Indianapolis.