Pittsburgh opens its prime time schedule Sunday night when they travel to Indianapolis to face the Colts.
Prior to the start of the season, this game appeared to be a matchup between two potential AFC favorites.
Mike Tomlin has coached the Steelers to a 5-4 record on Sunday Night Football, including a 4-3 record on the road.
Even with Manning absent, the Colts will present a challenge for the Steelers. Pittsburgh has gone on the road for Sunday night games before and have looked completely unprepared. They cannot allow this to happen this week.
Even in their shutout victory over the Seattle Seahawks last week, Pittsburgh did not look particularly crisp.
Dwight Freeney and Robert Mathis will lead a feisty Colts defense against a Steelers offense which is still trying to find its rhythm. They will be aided by what figures to be a rowdy Lucas Oil Stadium, though many Steelers fans are expected to be in attendance.
The eyes of the nation will be on the Steelers Sunday night, and they will want to show that they are still contenders in the AFC and improve their record to 2-1.