Every week people look for the best upset pick so that they can make some bank.
Vegas bookies are a lot smarter than we are, so it's always difficult to find the perfect underdog who will upset the favorite.
The next five upsets may be bold, but there's a strong chance that some of them will happen. Here are five bold predictions of underdogs covering the spread in Week 3.
Generally speaking, underdog teams tend to treat these big prime-time television games as extremely important ones. The whole country is watching and the Colts don't want to be embarrassed in front of the nation.
Kerry Collins knows this and he's a veteran quarterback. He's had a few weeks now to try to grasp the complex Colts offense. He was able to penetrate into the Browns' offensive zone several times last week but the Colts were only able to settle for field goals.
Life may be tough without Manning, but expect every single Indianapolis Colts player to rise to the occasion on Sunday night. If it's one game they want to win, it will be this one.
On the other side of the ball, the Pittsburgh Steelers look old. They don't seem like the same team from last year. That being said, they will win this game but it'll be close. The 10.5-point spread is too big.
The Steelers also don't have an explosive offense that will blow the Colts away quickly. Sure, they crushed the Seahawks last week. But that was at home and it was against a team that has historically played horribly on the east coast.
This game will go right down to the wire, and even if it doesn't the Colts will be able to stay within striking distance.
Final score prediction: Colts 16, Steelers 21
The Green Bay Packers have lost at Soldier Field in the regular season in three of the last four meetings.
Listen, the Packers may be the defending Super Bowl champions, but this matchup against the Bears is a divisional rivalry. It's possibly one of the best rivalries in sports. This means that all records are thrown away when these two teams meet. Anything goes.
The Packers have won eight consecutive games dating back to last season, including the playoffs. However, the Bears are no slouch. They won the NFC North for a reason last season. They have a strong defense and they've proven it this year in their 30-12 rout over Super Bowl contender Atlanta. They'll be in front of their home crowd and this should give them an advantage.
It's important to note that the Bears family was struck with tragedy as Brian Urlacher's mother unexpectedly passed away. Urlacher was playing with a heavy heart and struggled on the field. With time to grieve, he'll be more motivated to play well to honor his mother against the Bears' biggest rival.
It won't be easy, but the Bears will not only cover the spread, they will win, too.
Final score prediction: Bears 24, Packers 21
The Seattle Seahawks are one of the worst teams in the league and they've shown it this year in two blowout road losses.
But that was on the road.
The Seahawks fly home to open their schedule at CenturyLink Field against the Arizona Cardinals. Seattle has always been a different team at home. They have arguably the best home advantage in the league. The 12th man factor means a lot in the Great Northwest.
It wasn't long ago when the 7-9 Seahawks pulled off an upset for the ages, shocking the New Orleans Saints in the NFC Wild Card game.
Their opponent this Sunday is divisional rival Arizona. The Seahawks have only lost twice to the Cardinals at home in their last eight meetings in Seattle, and the two times they lost to them was when a guy named Kurt Warner was quarterback for the Cardinals.
So pretty much, the Seahawks own the Cardinals at home and expect this to continue Sunday as the 12th man will play a major factor.
Final score prediction: Seahawks 20, Cardinals 13
The Saints have their home crowd behind them, but the Texans have shown in the last two weeks that they are ready to compete.
New Orleans defense is pretty leaky when they face a good quarterback, as evidenced by the way Aaron Rodgers picked them apart so easily in Week 1. Matt Schaub is a type of quarterback who will make the Saints defense pay. He has elite threats in Owen Daniels and Andre Johnson and a solid running game with Arian Foster to mix things up.
The Texans defense has also improved tremendously. It was their weakness last season, but this year they've allowed a league-low 20 points. Although it was against inferior opponents, the fact that they have really come together defensively is a great thing for the Texans.
It'll be a lot more difficult stopping Drew Brees at the Superdome than it was stopping the Peyton Manning-less Indianapolis Colts, but the Texans have their own offensive weapons as discussed above and their defense is enough to contain the Saints' high-flying offense.
Expect a close shootout.
Final score prediction: Texans 34, Saints 31
It's actually very surprising that the Falcons are underdogs in this game, and it really won't be a big surprise if they win.
Matty Ice has a 5-1 record against the Bucs throughout his career, including a five-game winning streak against them. The Falcons as a whole perform well against the Bucs. Their running game is alive and well with Michael Turner, and they really shouldn't have any problems beating the Bucs.
Final score prediction: Falcons 24, Bucs 14