The Ravens feature a stout defense and a much-improved offense, while the Titans play hard-nosed physical football and have one of the NFL's elite rushing attacks.
The two teams will meet for the first time since 2008, and they will look to restore one of the AFC's best rivalry games.
The Ravens are the clear favorites going into the game after their Week 1 thrashing of their division rival Pittsburgh Steelers, while Tennessee lost to a Jacksonville Jaguars team that had cut starting quarterback David Garrard just a few days earlier.
The Titans will need Chris Johnson to be on his A game during this week's home opener if they stand a chance to upset the Ravens.
Here are five things to look for during Sunday's game.