Manning was considered doubtful for the game, as the Colts released a statement regarding his availability Monday. It has not been announced whether or not Manning will play or practice next week.
The team had announced previously that if Manning was unable to play the opening game that new free agent acquisition Kerry Collins will be the starter, not long-time backup Curtis Painter.
Collins signed Aug. 24. He played in only one preseason game for the Colts, going 5-for-10 for 45 yards against the Bengals last Thursday.
It remains unclear how long Manning will be out after Week 1.
It is the end of an era, really, for Colts fans. Since 1998, fans have never seen another quarterback under center in a game situation that was really important to the team. Manning had started every game for the team since '98.
The only time he wasn't on the field with the offense was when the team had locked up a playoff appearance and the team had decided to rest its franchise quarterback for the playoffs.