The Carolina Panthers will kick off the season in Arizona, the venue of Cam Newton's final collegiate performance, a win in the National Championship game over Oregon.
Both teams have made some big changes and we can't be sure of anything at this point. The preseason is rarely an accurate indicator of regular season success, making Week 1 the hardest time to make a prediction.
The Panthers and Cardinals are widely recognized at teams on the rise and for good reason. They've both upgraded the quarterback position and when you were at the cellar of the NFC last season, there is only room for growth.
Here is a breakdown of the positional advantages that each team has heading into this match-up.