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The Saints made it clear that they were going to play hard from the get-go (especially from the defensive side). Ignoring the traditional approach of bringing vanilla rushes in preseason games, New Orleans head coach Sean Payton brought the blitz 18 times.
Welcome to the NFL, Coach Harbaugh!
While Harbaugh had to have known the lockout was going to have an adverse effect on his team's readiness for the season, he may not have realized the issues he would have to overcome.
The offensive line at this point is more offensive than line. There are some major holes to fill in the defense, particularly in the secondary. There is no clear winner in the battle for the starting quarterback job.
The Niners as they stand just aren't ready for the regular season. Like I said before, there is still much work left to do.
Despite these difficulties, Harbaugh shouldn't be too critical about not leaving Friday's game with the win.
While the preseason is important in terms of determining starting lineups and getting players up to game speed, that readiness is not directly connected to wins and losses.
As a good example of this, the Niners were a perfect 4-0 last postseason under then-head coach Mike Singletary. That early success led to a not so impressive 6-10 in the regular season.