If they do, these players would follow former Astros' third basemen Jeff Keppinger, who was traded to the San Francisco Giants this week.
As the worst team in the league, major trades are imminent. They are looking to give up Pence, their best player, for two to four future contributors to the major league club. Who is desperate enough to do that?
Many teams are considering just that, although Houston will have to see the perfect deal on the table to part-ways with their star.
Obviously Pence has been in trade talks for a while, but who are the other players generating the most interest?
Here are the three players that are being talked about the most.