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The Texans have one of the most powerful offenses in football, and the Colts know that better than anyone.
In the opening game of last season, Houston lit up the Colts defense for 34 points behind Arian Foster's three touchdowns and 231 yards rushing.
The two met later in the season, and the Colts defense held the Texans to just 17 points.
They split the season series, but even though that doesn't sound like much, that is an improvement for the up-and-coming Houston squad.
The Texans ranked third in the league in total offense last season, averaging 386.6 yards per game, and ninth in the league in points per game with 24.4.
Wide receiver Andre Johnson could cause a lot of problems for the Indianapolis secondary that lost Pro Bowler Bob Sanders.
Arian Foster had a breakout season last season, winning the rushing title and scoring 16 rushing touchdowns.
The Texans high-powered offense led by quarterback Matt Schaub will be a tough matchup for the Colts defense this season and for many seasons to come.