NFL Week 6 Picks: 5 Blowouts Set To Happen This Weekend

In Week 5, the NFL saw the Detroit Lions lay the smack down on the St. Louis Rams, 44-6.

Given the Lions 0-4 record heading into the game and St. Louis' 2-2 record, it seemed to be an unlikely beat down.

Sometimes that happens in the NFL, but most of the time fans can suspect when a blowout is coming, a la the Jets 38-14 Week 4 thrashing of the Buffalo Bills.

With that in mind, here are four blowouts most are probably anticipating in the NFL during Week 6 and one special blowout that most don't see coming.

No. 1: San Diego Chargers at St. Louis Rams

Ezra Shaw/Getty Images

OAKLAND, CA - OCTOBER 10: Philip Rivers #17 of the San Diego Chargers huddles his team together during their game against the Oakland Raiders at Oakland-Alameda County Coliseum on October 10, 2010 in Oakland, California. (Photo by Ezra Shaw/Getty Images

Last week the Rams got blown out on the road.

This week they will get blown out at home.

The Chargers travel to St. Louis in Week 6 after special teams miscues cost them a road victory against Oakland in Week 5.

Sam Bradford and the Rams will have to suffer the wrath of an angry Philip Rivers and a 2-3 Chargers team that is first in the NFL in total offense and second in total defense.

The Rams are a young team that have played a slate of games against less than stellar competition. The Chargers are the best team they will have faced come Week 6.

The Chargers are more talented than the Rams and they're angry. As 8.5 point favorites, expect the Chargers to win by more than two touchdowns.

No. 2: Cleveland Browns at Pittsburgh Steelers

Jared Wickerham/Getty Images

PITTSBURGH - SEPTEMBER 02: Ben Roethlisberger #7 of the Pittsburgh Steelers laughs on the sideline during the 4th quarter against the Carolina Panthers during the preseason game on September 2, 2010 at Heinz Field in Pittsburgh, Pennsylvania. (Photo by

Big Ben is back.

And he is back in time for a delicious matchup against the Cleveland Browns at Heinz Field.

Pittsburgh fans are going to be loud and will gladly welcome back their tarnished quarterback. He will be glad to be back.

Let's face it, while they may have some moral disdain for his actions, the Pittsburgh fans realize their 32nd ranked pass attack will not suffice. Only Roethlisberger will change that.

He will probably be a bit rusty, but the momentum the home crowd supplies him will spur Roethlisberger on to success against a stingy Cleveland defense.

But the bread and butter of the Steelers is defense. And with Colt McCoy most likely making his first start in the NFL, the Steelers should have no problem covering the 14 point spread on Sunday.

No. 3: Detroit Lions at New York Giants

Chris Graythen/Getty Images

HOUSTON - OCTOBER 10: Head coach Tom Coughlin of the New York Giants during the game against the Houston Texans at Reliant Stadium on October 10, 2010 in Houston, Texas. (Photo by Chris Graythen/Getty Images)

First the NFL giveth and then it taketh away.

The Detroit Lions will be on the opposite side of a blowout the week after enjoying a blowout of their own.

For the Giants, they were being counted out after a pitiful display at home against the Tennessee Titans. Reportedly, coach Tom Coughlin was again on the verge of losing his football team.

Two weeks later the Giants look like one of the teams to beat in the NFC.

That won't change this week.

The Giants have the No. 1 pass defense in the NFL, allowing just 146 yards per game. The Lions offensive strength is their passing game. On the flip side, the Giants well-rounded offense will be too much for the Lions sub-par defense.

The Giants keep the good vibes going at home to continually make the Titans disaster a distant memory by covering the 10 point spread and then some.

No. 4: Seattle Seahawks at Chicago Bears

Geoff Burke/Getty Images

CHARLOTTE, NC - OCTOBER 10: Quarterback Jimmy Clausen #2 of the Carolina Panthers throws the ball over defensive end Julius Peppers #90 of the Chicago Bears at Bank of America Stadium on October 10, 2010 in Charlotte, North Carolina. (Photo by Geoff Burke

The Seahawks offense is fairly abysmal.

The Bears defense is fairly outstanding.

Those two facts combined with a Bears home game for the first time in three weeks should result in a blowout for the Chicago Bears.

The Seahawks have proved that they can stop the opponents ground game so far this season, limiting teams to 72.8 yards on the ground per game, second in the NFL.

But the Bears don't need to run the ball like they did in Week 5 when they had 40 carries from their running backs and just 19 pass attempts. That's because Jay Cutler is coming back from his concussion suffered in Week 4 against the Giants.

The only other weakness for the Bears in this game, quarterback protection, won't be as much as a problem against the Seahawks.

Bears ride the home crowd to a defensive driven blowout, covering the 6.5 point spread by two or more touchdowns.

No. 5: Indianapolis Colts at Washington Redskins

Scott Boehm/Getty Images

INDIANAPOLIS, IN - OCTOBER 10: Peyton Manning #18 of the Indianapolis Colts passes the football against the Kansas City Chiefs at Lucas Oil Stadium on October 10, 2010 in Indianapolis, Indiana. (Photo by Scott Boehm/Getty Images)

Maybe this is a bit of a cop out as a "surprise blowout," but the spread for this game is just three points.

This could get ugly if the Redskins pass defense is as bad as their ranking would indicate. Peyton Manning is on fire this season. His lone bad outing came last week against Romeo Crennel, who routinely befuddled Manning while he was the defensive coordinator of the New England Patriots in the early 2000s.

Manning will be looking to rebound and get back on track with his offense.

If the Colts have one weakness, it is their struggle to stop their opponents running backs. On the season, they have allowed 142.2 yards per game on the ground. But the Redskins only average 88.6 yards per game on the ground.

The Colts weakness cannot be exploited by the Redskins. But the Redskins weakness can be exploited by the Colts.

That is the formula for a blowout.