The loss of Justin Smith for several weeks made apparent their lack of depth along the defensive line. Injuries have decimated their wide receiving corps for the second straight year. Less obvious but just as important, they are thin at the defensive back position. Both safety positions and cornerback are areas they would like to increase their depth at in the event of injury or the loss of Dashon Goldson to free agency this offseason.
In the first round last year San Francisco chose wide receiver A.J. Jenkins out of Illinois, and he has been completely non-existent this season. I would assume San Francisco would not like to take another first-rounder who not only does not suit up for most of their games but also contributes virtually nothing on the days that he does make the active roster.
With that, the following five players are prospects the 49ers could take in the first round and who could provide immediate contributions, whether as a starter or a backup who earns significant playing time.