Justin Blackmon vs. Tennessee Titans
After being nearly non-existant for the entire season, Blackmon finally showed NFL fans why he was a top-10 draft pick this past year. He was nearly unstoppable, catching seven passes for 236 yards and one touchdown.
With Chad Henne set to start again, he is going to continue to target Blackmon, who should have no trouble getting open against the Titans' 26th-ranked pass defense.
Michael Crabtree vs. New Orleans Saints
In his last two games with Alex Smith as the starting quarterback, Crabtree has caught 10 passes for 142 yards and three touchdowns.
Assuming Smith returns from his concussion for Week 12, Crabtree will continue this touchdown streak. The Saints defense is one of the worst in NFL history, allowing over 460 yards of offense per game.
Even if Smith is not able to go, Crabtree is still worth starting because of how horrible the Saints secondary has been playing this season.