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Carson Palmer vs. New Orleans Saints
Palmer has been on a tear lately, throwing for 782 yards and six touchdowns in his last two games. Going up against the Saints defense, which is the worst in the league, Palmer should throw for at least 350 yards and two touchdowns.
Andrew Luck vs. New England Patriots
Luck has been playing terrific as of late, racking up 957 passing yards and five total touchdowns in his last three games. With the Indianapolis Colts in playoff contention, expect Luck to continue to carry this team.
Going up against the Patriots, who have that 29th-ranked pass defense, Luck will have his fourth solid outing in a row.
Joe Flacco vs. Pittsburgh Steelers
Flacco is coming off one of his best games in his career, in which he threw for 341 yards and three touchdowns while also rushing for one.
Here is the thing though: Flacco is awful on the road. In his four road games this season, he has only thrown for more than 200 yards once, and he has only three touchdown passes total.
Going up against the Steelers' top-ranked pass defense in Pittsburgh, expect Flacco to be a dud this week.
Matt Ryan vs. Arizona Cardinals
This doesn't mean Ryan is going to be a dud this week, but I would not expect him to put up the great numbers he usually does. The Cardinals have the second-best pass defense in the NFL and are allowing fewer than 200 passing yards per game.
Ryan is most likely the best quarterback on your fantasy football roster so he will be in your starting lineup, but don't be surprised if he has a mediocre game this week.