When Marcus Lattimore went down with a gruesome and unfortunate leg injury, everyone felt for him.
After rehabilitating from a torn ACL last season, the super-skilled running back faces another uphill battle.
The injury also significantly affects the way the 2013 first round will ultimately shake out in April.
Here's an updated, post-Lattimore injury mock draft.
Smith is the most prolific quarterback in this class, and the Matt Cassel experiment is certainly over.
The Jaguars could trade this pick, and although left tackle Eugene Monroe is solid, they could use an upgrade on the right side of their offensive line.
The Rams need to give Sam Braford more receiving talent. How about a chain-mover with size and strong hands? Keenan Allen's the guy.
The Panthers must add quality talent to their secondary. Milliner is the most polished cornerback in the class.
Sam Montgomery is the preeminent pass-rusher in the class, and the Browns need to add more skill in that department.
Jarvis Jones is a versatile edge-rusher who's been extremely productive in the SEC. The Titans have 14 sacks in eight games this year.
The Chargers need to find a sturdy left tackle to protect Philip Rivers. Jared Gaither is a rare talent, but injury concerns linger. Lewan is long and athletic, and the right choice here.
The Saints allow five yards per carry this season. They need a disruptive defensive tackle. Lotulelei is disruptive, and about as good as it gets in that department.
The Eagles secondary, after being ultra-hyped going into the 2011 season, has disappointed. Banks is a solid investment here.
Carson Palmer has played better in 2012 than he did a year ago, but he's not the future. If healthy, Wilson is a special talent and has elite potential.
The Rams grabbed Keenan Allen at No. 3, and they add priority No. 2 here with Matthews. Bradford must be protected much better.
The Cardinals would love an offensive tackle, but they love taking the best player available. Okafor is a rangy pass-rusher who will be welcomed by an improving defense in the NFC.
The Jets are in dire need of receiving talent. Woods may not be as incredible as teammate Marquise Lee, but he has great separation skills and is a refined YAC playmaker.
The Bills organization has to lay a new foundation with a franchise quarterback. At this point, Barkley's easily the best option.
Think a linebacker would help the Lions defense? I do. Te'o is a legit Heisman candidate with great sideline-to-sideline speed.
The Colts need to build the team around Andrew Luck. Therefore, the offensive line is priority No. 1. Warmack is huge and has plenty of experience against top competition.
Hankins is enormous, but he can really move and causes major trouble in the opposition's backfield with power and deceptive speed. Greg Schiano wants to construct an aggressive defense. Perfect.
If the Dolphins don't add a wide receiver in free agency, they'll have to add one in the draft. Hunter is 6'4'' with big play potential, ideal for Ryan Tannehill.
If Russell Wilson is to mature at the quarterback spot, the Seahawks need more help at wide receiver. Williams is lanky, but has amazing straight-line speed. Exquisite for a team that utilizes a ton of play-action.
Although Tony Romo's been sacked only 13 times on the year, he's running for his life far too often. Jones is a cerebral offensive lineman who can play three or four spots at the next level.
The Bengals secondary has taken a step back this year, and a lot of that has to do with poor play at safety.
Vaccaro's game is well-rounded, and defensive coordinator Mike Zimmer will love it.
Remember the glory days in Minnesota with Pat and Kevin Williams? John Jenkins is massive and athletic for his size. A nice building block for an improving defense.
The Ravens need to begin reconstructing their defense. Mosley is a heady and athletic linebacker who will team up with former teammate Courtney Upshaw to represent the wave of the future in Baltimore.
McDonald is a super athletic big hitter with adequate ball skills. If he learns the nuances of playing in an NFL secondary from Charles Woodson, he could be special.
Mingo is raw and hasn't stood out as frequently this year as many expected he would, but the Steelers love versatile defenders. James Harrison's days are numbered.
Imagine Tyler Eifert and Vernon Davis in jumbo packages in San Francisco. A scary proposition for the rest of the NFC.
Williams is flying under the radar, just how Bill Belichick likes it. He is being groomed to eventually fill Vince Wilfork's spot.
The Giants still have a weakness in their secondary. Amerson hasn't been as impressive as he was last year, but he's a huge corner and has tremendous ball skills.
The Broncos must find a quality safety in the offseason. There aren't many holes in Reid's game, a three-year starter at LSU.
Fluker is 6'6'' and 335 pounds, and would be a welcome addition to a Bears offensive line that undoubtedly needs depth.
It seems like the Houston Texans have been looking for an adequate complement for Andre Johnson for years. They drafted Keshawn Martin in 2012, but Austin is exceptionally gifted and will wreak havoc from the slot.
Michael Turner is in the twilight of his career. The best running back in the 2013 class? North Carolina's Giovani Bernard. Multifaceted, shifty, great vision and burst. Ideal for the Falcons' athletic offense.