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The biggest injury blow dealt to fantasy owners in Week 1 occurred in the Big Apple, where Buffalo Bills running back Fred Jackson suffered a sprained knee in the team's blowout loss to the New York Jets.
The 31-year-old told Jay Skurski of The Buffalo News that he was targeting Week 4 for his return, but that appears to have been overly optimistic given head coach Chan Gailey's comments to Chris Brown of the Bills' website.
“It’s going to be a few weeks," said head coach Chan Gailey. "It’s not going to be three, but I don’t think it’s going to be eight, but it’s probably somewhere in there in between. Hopefully sooner than later.”
That thrusts third-year pro C.J. Spiller into the starting lineup for the foreseeable future, and after racking up over 190 total yards last week, Spiller is a very solid fantasy start this week in a favorable matchup against the Kansas City Chiefs.
Jackson owners have little choice but to hold and hope for the best, although those in shallow leagues may want to seriously consider cutting bait if other options are available on the waiver wire given that there's no guarantee when Jackson will return or to what role in the Buffalo offense.