Everybody will have their eyes on star quarterback Peyton Manning, who is making his regular season debut for the Denver Broncos after spending 14 seasons with the Indianapolis Colts.
Will he have much success against a Steelers defense that ranked No. 1 against the pass and run last season? That remains to be seen, but Manning will have a strong running back in Willis McGahee, who will help give the offense some needed balance.
Manning will have to build some chemistry with his new receivers, but he does have plenty of quality options in the passing game. Demaryius Thomas and Eric Decker are two fantastic receivers, and each has the speed and route running ability to make some fantastic plays this season.
Thomas and Decker combined for 895 receiving yards and 10 touchdowns last year, but with a quarterback of Manning's caliber, both players could have breakout seasons in 2012.
The Steelers have won four of their last five season openers, but they did lose on the road 35-7 against the Baltimore Ravens to start the 2011 season.
Pittsburgh will be very motivated this season after having its three-year reign in the AFC North end last year when Baltimore won the division. Winning the division is a huge advantage for the Steelers because Heinz Field in Pittsburgh is one of the toughest stadiums to play in during the playoffs.
This is one of the most anticipated matchups of the season's first week, and it should be a fantastic battle between two elite quarterbacks.
Who will win this game?
Sunday Night Football TV and Start Time info for Week 1
When: Sunday, September 9 at 8:20 p.m. ET
Where: Sports Authority Field at Mile High, Denver, CO
Nicholas Goss is a Featured Columnist at Bleacher Report, follow him on Twitter.