Outside of elite-level guys, no one is really guaranteed a roster spot this early in the season. To make the final 53, some will have to put in the extra effort.
Some well-known veterans will fall by the wayside this preseason, and the following are the most likely.
Wide receiver Michael Jenkins kicks off our list as an out-of-place veteran in a tough spot.
The Vikings are getting younger, and Jenkins doesn't really figure to be too involved in the Minnesota offense come the 2012 season.
With Percy Harvin, Jerome Simpson and Jarius Wright already locking up spots, the team may cut its losses with Jenkins.
After breakout campaigns from Rob Gronkowski and Aaron Hernandez, the Visanthe Shiancoe signing was confusing for many New England fans.
Shiancoe may just be a warm body for training camp, and it's doubtful that this once-solid player even cracks Bill Belichick's final 53-man roster.
It wouldn't be a major upset if this player made the team, but the former Viking likely won't.
The Chargers didn't expect Ryan Mathews to get injured, but when the star rusher went down, the team realized its lack of talent behind the feature running back.
Ronnie Brown is nothing special anymore, being more of a liability running the football than he is an asset.
Brown is taking away reps from younger backs, and it's only a matter of time before the team cuts ties with this washed-up athlete.
The Browns recently drafted Trent Richardson, and Brandon Jackson is a better candidate to win the No. 2 job.
This leaves Montario Hardesty, a former Cleveland draftee who just can't get it right in the league and doesn't make much sense for the team anymore.
Look for Hardesty to lose out to Jackson and eventually find himself on the free-agent market.
The beginning of one era is the end of another in Washington, as longtime fan favorite Chris Cooley could be a roster casualty going into the 2012 season.
Cooley just isn't as good as the younger players on this team, and he'll have a tough time carving out his niche with the likes of Fred Davis stepping up big time.
While it's tough to see this player go, he had a great run in Washington and will be remembered in a positive light by Redskins fans.
After the Packers signed running back Cedric Benson, it became clear that another Green Bay rusher would have to go.
Alex Green has played and practiced well this preseason, so it seems as though James Starks is the odd man out in this backfield.
Green does everything that Starks does, and he has more upside. This rusher likely won't make the final roster.
Knowshon Moreno is another running back who has slid down the depth chart on his respective team, this time in Denver.
Willis McGahee is the feature back, and Lance Ball serves as a shifty scat back, leaving Moreno no place in a crowded backfield.
The runner is talented, certainly, but he needs to find a place with another squad.