Wells has had a phenomenal start to the season, rushing for 183 yards and two touchdowns on 32 carries in the first two contests after struggling mightily in 2010.
But after a reported hamstring injury in practice this week, Wells has been listed as "questionable" for the game and may not be able to play.
If it is at all possible, however, I think he will be on the field Sunday.
One reason Wells has a good chance of playing is because of the injury to backup runner LaRod Stephens-Howling. If Stephens-Howling can't go, then the Cardinals' running back depth will be severely lacking. Wells is far and away the team's leading rusher, and having him back would be ideal.
Another reason for pushing Wells into action is the fact that it's a division game. In many games it would be worth sitting Wells and letting him get 100 percent healthy, but if the injury isn't too bad, the Cardinals should give themselves every opportunity to get a leg up in the NFC West.
Of course the other side of the argument is if Wells plays and ends up complicating the injury, it could come back to bite the Cardinals. Not only that, but it isn't as if the 0-2 Seahawks are going to be a particularly stiff test. The newly-acquired Chester Taylor would probably be an adequate replacement for Wells for a game if Stephens-Howling is also out.
The bottom line is, Wells' injury is a game-time decision, and we won't know if he'll play until Arizona's first offensive possession.
But if the injury isn't too serious, expect to see him out there.