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Tramon Williams, Nick Collins, and Charles Woodson combined for 12 interceptions and 45 passes defended in 2010.
After an outstanding year in 2009, Drew Brees slumped somewhat in the 2010 season, throwing a career-high 22 interceptions and fumbling nine times, as well as being bothered by a knee injury throughout the season. Brees did still throw for 4,620 yards and 33 touchdowns, amassing a passer rating of 90.9
Despite the 2010 "slump", Brees is still one of the NFL's elite quarterbacks, and will be a huge factor in the season opener.
Brees has plenty of targets who are capable of getting open in the defensive backfield, most notably Marques Colston and Devery Henderson. The Saints running backs also play important roles in their passing game.
The Packers secondary had a huge year in 2010, holding opponents to just 194.2 passing yards per game, which was fifth-best in the league.
The trio of Charles Woodson, Tramon Williams, and Sam Shields evolved into one of the better cornerback groups in the NFL, and safety Nick Collins played another Pro Bowl-caliber season.
Second-year safety Morgan Burnett is returning from a season-ending knee injury in 2010, and has shown his big-hit ability so far this preseason.
The Packers also have depth in their defensive backfield, as injuries last year forced inexperienced players into starting roles. Charlie Peprah, Jarrett Bush, and Pat Lee all saw playing time when starters went down last season, and rookie Davon House has impressed coaches in the preseason.
Green Bay's secondary plays very physical defense, and has the ability to disrupt routes and cause turnovers. Drew Brees will need to play a smart game in order to limit Green Bay takeaways.