The two powerhouses have been feuding for decades. And like any good feud, they can fight over anything.
Some of the biggest blows in this rivalry have come off the field.
The Yankees landed some big ones when they one-upped the Sox in the trade battle for Alex Rodriguez, then continued to kick them while they were down by trading for Bartolo Colon to be the ace of their staff and convincing Mark Teixiera to spurn them in the 2010 offseason.
But like any good feud, the Sox bounced back with the signing of Carl Crawford and the trade for Adrian Gonzalez.
This season the battle will be over pitching. Both squads need help in the starting rotation as well as the bullpen.
Here are 10 pitchers the Red Sox and the Yankees will be fighting over in the weeks to come.