A dozen aces from 12 different teams will walk out to the mound today as Major League Baseball gets underway in six different cities across America.
Justin Verlander and CC Sabathia match up at Yankee Stadium in the best pitching duels of the early starts, while the Brewers-Reds game highlights the three 2pm starts.
Later, Tim Lincecum gets the ball for the reigning World Series champion San Francisco Giants as they start the defense of their crown against the LA Dodgers in the first night game of the 2011 season.
What history will be made on the first day of baseball's latest season? How will it compare to seasons past? We'll just have to wait and find out.
To whet your appetite, here are 20 moments, facts, statistics and figures from 20 different Opening Days from previous years.