From rules to uniforms to playing surface to the Red Zone channel, The NFL has changed tremendously since it's beginning.
However, the one aspect that remains the same is the great quarterback to receiver combo.
From Meredith and Hayes to Montana and Rice, the NFL has never been without deadly quarterback and receiver combos.
Here is a list ranking the top deadly passing combinations in the league today.
It was supposed to be a tough transition for Anquan Boldin to go from Larry Fitzgerald's sidekick to the number one receiver for a team contending for the playoffs, but so far, he has made it look easy.
The two have had their ups and downs this year and that is why they rest at the bottom of the list, but when these two are completely healthy and on the same page, opponents better watch out.
Unless you own him in your fantasy football league, you probably didn't know that Dwayne Bowe leads the NFL in receiving touchdowns and has racked up the seventh most yards of all pass catchers.
With Matt Cassel finally regaining his 2008 form and getting comfortable with his number one receiver, these two Chiefs should be a deadly combination for many years to come.
What an awesome bro hug.
Doesn't the picture say it all? These two players have such good chemistry it almost seems automatic.
When the world champion Saints have to convert a third down or are in smelling distance of pay dirt, Colston is undoubtedly Drew Brees' go-to-guy.
Colston will probably eclipse the 1,000 yard mark yet again this season and come close to hooking up with his favorite QB for 10 touchdowns.
When Big Ben makes a big play, he is throwing it to Mike Wallace.
Wallace, the fastest receiver in the league, is on his way to becoming the greatest deep threat in the NFL and a perennial Pro Bowler.
These two have connected on 41 receptions for over 800 yards, eight touchdowns and 25 plays over 20 yards (six of those over 40 yards.)
If you haven't seen what these two can do, here you go.
This duo erupted onto the NFL scene this year and none of us saw it coming.
Despite being injured the past couple of weeks, Nicks has caught 62 passes for 800 yards and nine touchdowns from the other Manning so far this year.
Watch out for this happy couple in this year's postseason, because they can really light it up.
Is there really any debate that Michael Vick and Desean Jackson are the two fastest men on the field at any given point in time?
Sure, Jackson hasn't exactly racked up the yards and Vick hasn't played every game this season, but when these two are making plays, it sure is something special to watch.
Watch out for Vick and Jackson in this year's playoffs, because these two Eagles can really fly.
One day, Matt Ryan and Roddy White could be number one on this list.
Ryan and White have led the Atlanta Falcons to the best record in football and a current seven game winning streak.
Matty Ice has hurled himself into the elite quarterback conversation in just his third full season as the Falcons starter and Roddy White has put up some of the best numbers in the entire NFL (1,140 Yds, 95 YPG, 7 TD.)
Both are shoe-ins for this year's Pro Bowl and because of it, their team is a Super Bowl favorite.
Aaron Rodgers may have twice as many concussions as Troy Aikman when it is all said and done, but he is one of the greatest quarterbacks that this generation has ever seen.
Greg Jennings was catching passes from Brett Favre long before Rodgers became the starter in Green bay, but he and the old man were nothing like him and Rodgers are now.
Recently, the two have really started clicking on all cylinders and so far on the season they have connected for 11 touchdowns almost 1,000 yards.
Hopefully Rodgers recovers quickly so he and his favorite target can propel the Pack into the playoffs and continue to shred up secondaries.
Andre Johnson has already caught over 1,000 yards worth of passes from Matt Schaub and considering how incredible of a season he had last year, this year has been a disappointment.
Last season, Schaub and AJ produced over 1,500 yards and 31 plays of over 40 yards. Johnson is the definition of a deep threat.
When the Texans finally fire Gary Kubiak and hire a real coach, they should make it into the playoffs with ease. The big three of Matt Schaub, Andre Johnson, and Arian Foster make the Miami Heat look like the New Jersey Nets.
Even though Peyton Manning has decided to switch places with his brother and throw a thousand picks a game, he still manages to get the ball to his favorite target - Reggie Wayne.
These two have been the best quarterback-receiver duo in the NFL for many years and after all these years, they can still make it look easy.
In 2010, Wayne has been on the other end of 94 passes from his hall of fame QB for over 1,200 yards and five scores.
Until one of the two retires or has a career-ending injury, Manning and Wayne will likely remain on the top of this list.