WR Start: Mario Manningham, New York Giants
The Giants wide receiver position has been ravaged by injuries. With Hakeem Nicks and Steve Smith out, Manningham will get a major boost in targets and defensive attention.
Even with a full complement of wideouts, Manningham received 55 targets, and his rapport with Manning continues to augment week by week.
He has developed into a dynamic, big-play weapon with a 25-plus yard reception in seven of the eight games he's played.
After a 10-reception performance in Week 10 (16 targets), Manningham was targeted only three times last week. He should see a bounce back in activity against Jacksonville's putrid 28th ranked pass defense that's allowed 67 percent completions and 20 touchdowns through the air.
He's been presented with a golden opportunity to be "the man," and judging by his clutch ability, he will respond admirably.
WR Sit: Pierre Garcon, Indianapolis Colts
After exploding onto the scene in 2009-2010, Garcon has reverted back to raw form. He's second in the league in dropped passes, and appears to have lost confidence in his skills.
Even with Dallas Clark out (and Austin Collie missing time), Garcon is still seeing a decrease in traffic his direction (70 targets). Quite simply, Manning doesn't trust him.
He's capable of the spectacular, but those moments have been few and far between.
Garcon has been held scoreless and without a 20-yard reception for four consecutive weeks. His meal ticket was the deep ball, and that has all but vanished.
On the season, he has just one touchdown and one 100-yard game.
His luck is unlikely to change this week against the Chargers No. 1 rated pass defense. They've held opposing quarterbacks to a 74.8 QB rating and have allowed nine touchdowns against nine interceptions.
Sitting a wideout on a team quarterbacked by Manning is not an easy decision, but it's the prudent one.
QB Start: Ben Roethlisberger, Pittsburgh Steelers
In six starts since his return from suspension Roethlisberger has fallen into a pattern: two good, two bad, two good. If the pattern continues he's on pace for a poor effort on Sunday, but six games doesn't make a trend.
He followed up two sub-200-yard efforts with 387 (296 in the fourth quarter) and 275 in his last two starts with seven composite touchdowns. He also ran for 55 yards against Oakland, the largest single-game rushing figure of his career.
Overall, Roethlisberger sports the No. 3 passer rating in the NFL at 101.9 and a 12:4 touchdown to interception rate.
Pittsburgh's offensive attack is more pass heavy than in years past, utilizing the big play with speed on the outside. Mike Wallace caught long balls of 52 (TD), 37 and 27 last week and Big Ben averaged 9.5 yards per attempt.
Buffalo's pass defense ranks a respectable tenth, but that says more about their 32nd ranked rush defense than the quality of secondary play. They've allowed 20 passing touchdowns against just four interceptions forced (two last week).
QB Sit: Jon Kitna, Dallas Cowboys
Kitna has posted 124.1 and 129.7 QB ratings over the last two weeks. Despite only 46 total pass attempts in those starts, he's thrown six touchdown passes (one interception) and ran for a seventh score.