The Eagles have never beaten the Colts under Peyton Manning, who has great numbers against the Eagles. Colts are 3-0 against the Birds under Manning.
The Colts average margin of victory against the Eagles under Peyton Manning is 24 points. The Colts played Monday though, so it is a short week for them and they are very banged up.
Monday night teams who go on the road the next week traditionally do not do very well in that scenario, but then again, most of them do not have Peyton Manning.
The Colts have the 2nd ranked offense and 15th ranked defense, but struggle against the run, where they rank 27th. Manning's audibles at the line will confuse the Eagles and be hard for them to defend.
On the other hand, the Eagles have never lost coming off a bye since Andy Reid has been the coach (11-0).
The Eagles are also unbeaten this season when Michael Vick plays the whole game.
The Eagles have the 5th ranked offense and 11th ranked defense in the NFL.
The Eagles also have the home field advantage, although they are only 1-2 at home. Coming off a bye week is probably the biggest advantage though.
I have picked against the Eagles a lot this season, including against Tennessee, and I was correct there.
Sometimes you have to go with your gut instinct and for some reason, I think the Eagles are going to pull this game out.
Reid's great track record after a bye plus a short week for the banged up Colts is just a bad spot for them in my opinion.
Manning gets his, but the Eagles win a close one.
Eagles 31 Colts 27