Reggie Bush, say it isn't so.
The New Orleans Saints running back is out for at least six weeks due to an injury to his right leg obtained in last night's game against the San Francisco 49ers.
The Saints may have won the game, but they lost some serious offensive talent in Bush.
It's not even Week 3 of NFL football, but we've already seen several teams throughout the league lose some valuable players.
Here are the most devastating injuries of this NFL season and how they will affect each team.
Injury Report: Knee. Dixon injured his left knee during Sunday's game against the Tennessee Titans, and is not expected to be in playing shape for at least three weeks.
What Does This Mean?: We didn't expect Dixon to be playing beyond Week 4 anyway, so his absence will have minimal affect on the Steelers offense. Big Ben will be back soon, and while Dixon's injury is unfortunate, it is little cause for concern on the Pittsburgh offense.
Injury Report: Ankle. Delhomme is said to have aggravated his ankle in Week 1 against the Buccaneers and Seneca Wallace has taken his place as the starting quarterback. Coach Eric Mangini expressed his confidence in Delhomme's recovery yesterday to the Cleveland Plain Dealer, but it looks like Wallace will start against the Ravens.
What does this mean?: The Browns haven't had a strong quarterback (even with Delhomme) in years, so Delhomme's absence shouldn't be too great of a factor in the Browns' offense.
Seneca Wallace will be as good as anyone at the position. The Browns' problems reach far beyond quarterback.
Injury Report: Knee. Tight End, Billy Bajema, will miss 2-4 weeks due to an MCL injury obtained in Week 2 against the Raiders.
What Does This Mean?: The Rams are hurting at the tight end position with Daniel Fells also suffering from an MCL injury. With a rookie quarterback, tight ends are crucial in building the confidence of their offensive leader. So a rookie quarterback mixed with rookie tight ends does not spell success for the St. Louis Rams.
Injury Report: Hamstring. Revis aggravated a strained hamstring while being completely embarrassed by Randy Moss' ridiculous one-handed catch on Sunday. Revis could be sidelined for 1-2 weeks.
What Does This Mean?: Even though Revis held out for the big bucks with the New York Jets, the real star of the Jets' secondary is Antonio Cromartie. Cromartie stepped it up in Revis' absence against the Patriots, and the Jets should be able to make do without Revis for a few games.
Injury Report: Hip. Reed placed himself on the PUP list after undergoing hip surgery in May. Reed is expected to return in Week 7.
What Does This Mean?: The Ravens' defense seems to be doing fine without Reed, but missing one of the best safeties in the league is detrimental to any defense (just ask the Pittsburgh Steelers).
Injury Report: Head (concussion). Kevin Kolb suffered a concussion in Week 1 against the Green Bay Packers, and he was out for Week 2's game at the Detroit Lions. Kolb is expected to start in Week 3.
What Does This Mean?: Kolb will be fully recovered and back to playing shape against the Jaguars. The real devastation here is not the injury itself, but it is the controversy now surrounding the Eagles' quarterback situation.
With Kolb unable to play last Sunday, backup Michael Vick was given the chance to shine. And he did!
Kolb will remain the starter, but this decision has left many fans doubting Eagles coach, Andy Reid. Even though Kolb has retained his starting position, he will find himself on a tighter leash this season, and fans will be demanding Michael Vick if Kolb is anything but fantastic.
Injury Report: Shoulder. Stafford sustained an injury to his right shoulder in the Lions' season opener against the Bears. We know that he will not play until he is 100 percent, but Jim Schwartz is remaining vague about when Stafford will return.
What Does This Mean?: Shaun Hill will take over until Stafford is able to play, and the Lions held their own against the Eagles on Sunday. But questions at quarterback are never a good thing for team confidence, and the Lions will feel the effects of Stafford's absence.
Injury Report: Knee. Wells has been out for the first two games of the regular season, and he is questionable to start in Week 3.
What Does This Mean?: Tim Hightower has been given the majority of the carries on the Cardinals' offense, and he picked up some decent yardage against the Falcons.
But the Cardinals really need to get it going on offense if they are going to have a winning season.
Injury Report: Leg. Bush fractured his fibula during last night's game against the 49ers. He is expected to miss four to six weeks.
What Does This Mean?: So far this season, the Saints' offense has been anything but impressive. This could be because we are used to explosive performances by Drew Brees and company, but defenses around the league seem to have found an answer to the Saints' strategy.
Losing Bush, while not a death sentence for the Saints, will definitely impact the scoring ability of New Orleans.
Injury Report: Hip. Rice is recovering from preseason hip surgery and is said to be ready to play by Week 7.
What Does This Mean?: The Vikings are hurting pretty bad on offense in general, and Brett Favre's accuracy issues can be partially attributed to a lack of athleticism in his receiving corps. A trade for Vincent Jackson may be the temporary fix the Vikings need, but Rice's absence is definitely being felt in a big way in Minnesota.