Reggie Bush, say it isn't so.
The New Orleans Saints running back is out for at least six weeks due to an injury to his right leg obtained in last night's game against the San Francisco 49ers.
The Saints may have won the game, but they lost some serious offensive talent in Bush.
It's not even Week 3 of NFL football, but we've already seen several teams throughout the league lose some valuable players.
Here are the most devastating injuries of this NFL season and how they will affect each team.