Yesterday's announcement that Green Bay Packers running back Ryan Grant will miss the rest of the 2010 season is devastating news to Packer fans and inside the team locker room.
After back-to-back 1,200-yard seasons, Grant was emerging as one of the league's top backs.
Now, to make up for the loss, Aaron Rodgers will have to play even better than he did last season.
If the Packers don't reach the Super Bowl like many predicted just a week ago, Grant's injury will be reason No. 1 in most people's minds.
Here are 10 other cases in the past 10 years when an injury completely altered a team's fortunes.