Many injuries have happened so far this year, but there are plenty of players to make up for it.
Players like Ryan Grant, Reggie Bush, Knowshon Moreno and Ryan Matthews have all taken blows and on the shelf right now.
Performance has also been a big factor in replacements as well. We have already seen Kevin Kolb, Jason Campbell, Matt Moore, and Trent Edwards all lose their starting jobs.
Michael Vick has been a goldmine for people who took a shot on him on the wire. Here are the best waiver-wire pick-ups for Week 3:
Ryan Matthews sprained his ankle last week and is doubtful for Week 3.
Tolbert had 82 yards and two touchdowns stepping in for Matthews last week.
He will get the start and faces a weak Seattle defense. Pick him up and plug him into your lineup.
Knowshon Moreno pulled his hamstring in practice and is out for at least two weeks.
Maroney is the favorite to start, with Correll Buckhalter also getting some touches.
Both backs are worth picking up for some spot starts.
Tom Brady targeted Hernandez plenty of times last week with Randy Moss and Wes Welker held in check by the Jets defense.
This week he faces a Bills defense that just gave up four catches for 101 yards to Jermichael Finley.
Hernandez is worth a start if your tight end or flex option is shaky.
Lewis is off to a strong start this year. Lewis has 101 yards and two touchdowns through two weeks.
Lewis has become the second option for David Garrard through the air and has been very productive.
He is worth a pickup for a starter, bye week fill-in, or as a flex option.
I mentioned Lewis last week and his ownership is rising (53 pecent), so get him fast.
Orton has been playing like a top fantasy quarterback thus far.
Orton has 603 passing yards and three touchdowns in two games and now has another favorite weapon in Demaryius Thomas.
He's worth a pick-up if your starter is struggling or as a bye-week fill-in.
He's barely owned over the likes of Kevin Kolb and Alex Smith, yet is the 10th-ranked fantasy QB right now.
Thomas stepped up big last week in his first game of the year. He had eight catches for 98 yards and a touchdown.
He showed great rapport with Kyle Orton and looks like a nice find for the Broncos. Pick him up immediately.
Michael Turner hurt his groin last week, but Snelling filled in nicely with 186 combined yards.
He is at least a pickup for Turner owners as a handcuff, but needs to be owned in all leagues in case Turner gets hurt again.
Andre Johnson was injured late in the game last week and Walter became Matt Schaub's top option.
Walter is especially valuable in ppr leagues after he hauled in 11 catches for 144 yards.
Pick him up if he's available, because he has the upper hand over Jacoby Jones as the second option for Schaub.
Murphy clicked with Bruce Gradkowski last week, and with Gradkowski earning a start this week, he's worth a pickup.
Murphy had six catches for 91 yards and a touchdown last week and looks to be a viable option in the Raiders passing game right now.