1. Andre Johnson - This should be a high-scoring affair with lots of yards and points through the air. I expect the top fantasy receiver to cash in accordingly.
2. Reggie Wayne - Like Johnson, I expect a big performance from Reggie Wayne. Especially with Dunta Robinson no longer in Houston.
3. Miles Austin - Washington has been dealing with a lot of distractions this offseason. I don't doubt that Mike Shanahan will be prepared, but I do think Romo will connect with Austin for at least one big score.
4. Randy Moss - Cincinatti's defense was one of the NFL's toughest last year, which could cut into Moss' production in week 1.
5. Larry Fitzgerald - Derek Anderson's more likely to get a long ball to Fitz than Leinart would have been, and playing against the Rams, it's almost a guarantee.
6. Roddy White - Pittsburgh is much tougher against the pass with Troy Polamalu healthy.
7. Steve Smith (Car) - The Giants are banged up on defense, and Smith looked good in the games where Matt Moore was throwing at the end of last season.
8, Calvin Johnson - Detroit will likely be playing from behind in the second half, which means they'll let Stafford air it out to Johnson on multiple occasions.
9. Chad Ochocinco - The Patriots' defense looked awful against the pass in the preseason. Combine that with the Bengals' improved passing game, and Ochocinco could be in for a big day.
10. Brandon Marshall - The Bills actually ranked 2nd against the pass last year. Marshall will have some monster games for Miami this year, but this likely won't be one of them.
11. Malcolm Floyd - His ascent to the starting role has generated a lot of hype, and with a soft week 1 matchup against the Chiefs, he'll live up to it in week 1.
12. Greg Jennings - The Packers' offense looked insane in the preseason. Philly's pass defense wasn't anything special last year, so Jennings could put up some nice numbers here.
13. Percy Harvin - The migraines seem to be under control, and he looks like he'll open the season as Favre's no. 1 option, which bodes well for his week 1 production.
14. Marques Colston - The concern with Colston is never his ability but how good everyone else on the offense is, so trying to pick which Saints receiver will benefit from all the points Brees puts up is like guessing lottery numbers.
15. Johnny Knox - Mike Martz offense, Detroit Lions defense.
16. Desean Jackson - That Packers' D is scary. Jackson's ceiling is lower than usual this week.
17. Michael Crabtree - The Seahawks could be a complete disaster this year. If Crabtree is in sync with Alex Smith, they could pick this secondary apart all day long.
18. Pierre Garcon - Like Reggie Wayne, Garcon should benefit from what will likely be a high scoring game with the Texans.
19. Steve Smith (NYG) - Carolina's pass defense ranked 4th last year in the NFL. I don't see the Giants passing a lot this week.
20. Anquan Boldin - Vacationing on Revis Island.
21. Mike Wallace - Dennis Dixon is the team's third quarterback for a reason. I expect the Steelers to run a lot and try to control the clock in the first four weeks while Roethlisberger serves his suspension.
22. Jacoby Jones - He made a lot of noise in the preseason, and the chances of him getting some chances for a big score this week are good. The Texans and Colts love to pass.
23. Wes Welker - He may start slow this year coming off that knee injury. Facing the Bengals' defense could help make that start even slower.
24. Santana Moss - McNabb looks like he'll be good to go in week 1. Dallas' secondary has a lot of question marks, especially after the preseason, so Moss could do well here, especially if the 'skins are forced to play from behind.
25. Hines Ward - Ward's value will climb once Big Ben comes back. This week, he's got a potentially tough matchup against Atlanta's secondary (which added Dunta Robinson this year), and he'll have Dennis Dixon throwing to him.