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The Bills also haven't faced the Detroit Lions since 2006, and they lost 20-16, while quarterback Jon Kitna, running back KevinJones, and wide receiver Roy Williams destroyed the Bills.
Kitna passed for 278 yards and a touchdown, with 160 of those yards gained by Roy Williams. Kevin Jones ran over the Bills defensive line for 127 yards and a touchdown.
J.P. Losman went 21-34 for 237 yards, two touchdowns, and surprisingly, no interceptions, while McGahee rushed 17 times, for just 66 yards.
Lions defensive end, James Hall made three sacks, one in the fourth quarter that led to the Lions winning.
Now, both the Bills and Lions rosters have completely turned over, and now Matthew Stafford, Jahvid Best, and Calvin Johnson, will face Brian Brohm, C.J. Spiller, and Lee Evans.
Bills CB Terrence McGee Vs. Lions WR Calvin Johnson
Terrence McGee faces off against one of the best wide receivers in the National Football League in Calvin Johnson. Johnson is always a homerun threat, and if the ball is thrown in his vicinity, he is likely to catch it. He's huge and physical, so it will be interesting to see if the 5'10" McGee can cover the 6'5" Johnson.