Vincent Jackson, Marcus McNeill, and Shawne Merriman will not be playing on Saturday. They will need to be replaced should their holdouts continue into the regular season.
Jackson will have to be replaced by Malcom Floyd, leaving a spot open as the number two receiver.
Newly acquired Josh Reed should get the first look, followed by the four-year veteran Legedu Naanee, and 2007 first-round draft pick Buster Davis. Jackson's absence will also give undrafted rookie Seyi Ajirotutu, and former practice squad player Gary Banks a chance to get some snaps.
Marcus McNeill's left tackle spot will be filled by Brandyn Dombroski. Tra Thomas will get a shot to take the left tackle spot as well.
Last year's first round pick, Larry English, will try to fill the void in the starting lineup left by Merriman. James Holt spent most of the season on the practice squad last season, but expect him to make some plays at outside linebacker this preseason. Antwan Applewhite will also get some additional playing time.