NFL Week 16 Picks: Game Odds, Props, Lines and Over/Under Predictions

The NFL doesn't pull any punches this holiday season.

With playoff berths up for grabs, the NFL unrolls a Week 16 slate littered with divisional matchups and showdowns between contenders. A Thursday NFC East clash between the New York Giants and Philadelphia Eagles is just the beginning.

Bettors shouldn't hold back either. The mid-week lines offer plenty of value for those who don't want to worry about monitoring the situation right up until kickoffs on Saturday and Sunday.

Given the situation, let's take a look at the full set of odds and nail down some predictions.

NFL Week 16 Odds

Matchup	Spread	O/U	Predicted Winner
NY Giants at Philadelphia (TNF)	NYG -2.5	41.5	NYG 27-20
Minnesota at Green Bay	GB -6.5	43	GB 24-23
Tennessee at Jacksonville	TEN -4.5	44	TEN 30-23
Washington at Chicago	WAS -3.5	47	CHI 24-20
Miami at Buffalo	BUF -3.5	42	MIA 23-20
San Diego at Cleveland	SD -6	44	CLE 24-14
Atlanta at Carolina	ATL -3.5	53	ATL 33-30
NY Jets at New England	NE -16.5	44	NE 27-17
Indianapolis at Oakland	OAK -3.5	53	OAK 34-30
Tampa Bay at New Orleans	NO -3	52.5	TB 27-23
Arizona at Seattle	SEA -8.5	43.5	SEA 30-20
San Francisco at Los Angeles	LA -2	40	LA 17-14
Cincinnati at Houston	HOU -2	41	HOU 24-20
Baltimore at Pittsburgh	PIT -5	44	PIT 21-20
Denver at Kansas City	KC -4	37.5	KC 27-24
Detroit at Dallas (MNF)	DAL -7	43	DAL 28-24

Odds according to OddsShark.

San Diego (-6) at Cleveland

If the Cleveland Browns are getting a win this year, it's happening in Week 16. 

The San Diego Chargers look miserable. Not necessarily Cleveland miserable, but the team has lost three in a row and four of five, the most recent loss essentially a road game at home against the Oakland Raiders while the franchise flirts with a move.

Philip Rivers simply hasn't been able to compensate for losses of guys such as Keenan Allen and Danny Woodhead, among many others. He has 29 touchdowns to 18 interceptions, yet the ground game averages less than four yards per carry and the defense coughs up 26.1 points.

Cleveland, of course, has yet to win. But Robert Griffin III is back under center and scored a rushing touchdown in Week 15, gifting the offense some much-needed versatility.

This one comes down to gut feeling. Isaiah Crowell is one of the league's better backs yet doesn't see enough opportunities this year because the Browns fall behind so early in almost every game.

That should change this time out. Teams from out west have a hard time traveling across the country and playing in the snow. Cleveland fans, to their credit, will show up. It's a concoction worth throwing a little money down on, as the Browns will play in what amounts to their Super Bowl while hunting for the first win of the year against a team far away from home and struggling.

Prediction: Browns 24-14

Tampa Bay at New Orleans (-3)

Bettors shouldn't stray from the Tampa Bay Buccaneers now.

The Buccaneers took a loss to the red-hot Dallas Cowboys in Week 15 but before the hiccup had won five games in a row, boasting wins over contenders such as the Kansas City Chiefs and Seattle Seahawks.

Despite the gaffe, Jameis Winston still looks great and his defense still holds opponents to 23 points per game. Keep in mind, too, Winston outdueled Drew Brees in a Week 14, 16-11 victory against the New Orleans Saints.

In that contest, Brees tossed three interceptions, his team committed 13 penalties and could only covert four times on third down out of 13 attempts.

This isn't a shock. New Orleans doesn't look like a playoff team at all. It has lost four of its last six, the only wins coming against downtrodden Carolina Panthers and Arizona Cardinals teams. As usual, the Saints haven't been able to compensate for a defense coughing up 28 points per game and look like a team headed for a rebuild.

From a picks standpoint, New Orleans hasn't even been stellar at home this year, losing there four times. Tampa Bay, with so much at stake, will ride Doug Martin against a soft defense, setting up big plays through the air, keeping the Saints at an arm's length while completing the season sweep.

Prediction: Buccaneers 27-23

Detroit at Dallas (-7)

It's understandable if bettors want to run with the Cowboys and not really think about it too much. 

Not the worst move in the world, but a riskier one than usual with the Detroit Lions on tap. 

Those Lions boast nine wins and a top slot in the NFC North thanks to Matthew Stafford (22 touchdowns, eight interceptions), a knack for late comebacks and an underrated defense only allowing 20.4 points per game.

Granted, this one goes down in Dallas and few seem able to stop Ezekiel Elliott (1,551 yards, 13 touchdowns), but Detroit has a defense able to take advantage of rookie quarterback Dak Prescott, who has only a pair of touchdowns and interceptions over his past three outings.

The challenge for Detroit is passing on a Dallas defense only permitting 18.4 points per game. Stafford didn't throw a score in a Week 15 loss to the New York Giants, a 17-6 outcome as Odell Beckham Jr. scored a pair of touchdowns.

"Obviously, we lost the turnover battle, lost the rushing battle. It's tough to win on the road when you do that," Stafford said, according to the Associated Press (via ESPN.com). "We've got to look in the mirror and correct what we did wrong today."

If Detroit can stick by Stafford's words and correct mistakes, Dallas won't pull away in this one like Las Vegas suggests. The Detroit defense is quality and seems to have the right strengths in the right places to counter Dallas.

Elliott and the defense will have the Cowboys coming out on top like usual at home, but bettors will want to be very careful with the spread here.

Prediction: Cowboys 28-24

Stats courtesy of NFL.com. All advanced metrics courtesy of Pro Football Focus. 

Follow Chris Roling (@Chris_Roling) on Twitter.