Thomas J. Russo-USA TODAY Sports
Best-Case Scenario: Week 1 return
No one in the media is exactly sure what happened to EJ Manuel's knee in the Buffalo Bills' second preseason game against the Minnesota Vikings, and until the morning following the game, the rookie quarterback didn't know either.
Chris Brown of BuffaloBills.com wrote on Sunday that "Marrone was making an effort to classify EJ Manuel’s knee injury, which required surgery, as minor."
When asked if Manuel could play in the season opener against the New England Patriots, the former Syracuse head coach said, "He could. There is a good chance of that and the problem I have with that is again, a lot of it is just how he comes back."
Peter Schrager of FOX Sports reported via his sources that Manuel would be out two to four weeks after his "minor" procedure.
Therefore, the best-case scenario for Manuel is starting for Buffalo when the team hosts Tom Brady and the New England Patriots in Week 1.
Worst-Case Scenario: Available Week 3
Because the Bills are exercising their right to be relatively vague about Manuel's injury, it's extremely difficult to peg a worst-case scenario at this point.
Starting the season on PUP seems unlikely, so using the end of the initial prognosis appears to be the most logical worst-case scenario for Manuel.
Actually, though, Manuel's injury came at an awful time, as he now could lose the starting quarterback job in Buffalo he was primed to win.