The Pittsburgh Steelers will feast on a disappearing Tennessee Titans defense in Week 6 and earn the rarest of NFL victories: an easy road win.
They won't be the only road team to win, but others will face tougher challenges.
In Seattle, the Patriots have to face a hostile 12th Man crowd and a tough Seahawks defense, but they should still prevail.
And the surprise Vikings will roll into the nation's capital in an attempt to take down the Redskins.
Let's take a look at the details of these three matchups.
Week 6 Victim: Tennessee Titans
Of the three road teams highlighted here, the Steelers will have the easiest path to victory. The Titans have lost their two games leading up to this one by a combined score of 68-21.
They are struggling in all phases of the game, and it is their 29th-ranked sack percentage that will really doom them in this one.
The Steelers' offensive line has kept Ben Roethlisberger on his toes this season in an endless series of scrambles.
The Titans' weak pass rush will have a hard time even generating pressure against this poor offensive line, and their defense is headed towards another long day as a result.
On the other side of the ball, the Steelers defense has not been as nearly as imposing as the past few years, but they are still third in pass yards and 11th in rushing yards.
The Titans, who are 30th in rushing yards, but 16th in passing, are poorly equipped to get anything accomplished offensively against Pittsburgh.
Prediction: Steelers 31, Titans 20
New England Patriots
Week 6 Victim: Seattle Seahawks
The Seattle Seahawks are always tough at home, but at least the Patriots won't have to deal with replacement refs finding it an equally tough place to not make terrible calls.
This is actually one of the more intriguing matchups of the week. While the Patriots offense has looked unstoppable on the ground and through the air the last two weeks, they haven't faced a defense anywhere nears as tough as they will this week.
In fact, the only defense they've faced comparable to the Seahawks is the Arizona Cardinals (no, the Ravens defense is no longer elite) and the Patriots managed just 18 points en route to the loss.
Defensively, the Seahawks enter this game fifth in passing yards and third in rushing yards. We will know exactly how beastly this Patriots' offense is after this one.
However, while the Seahawks defense should be able to at least slow down New England, it won't be enough for their struggling offense to outscore the Pats.
Prediction: Patriots 27, Seahawks 17
Week 6 Victim: Washington Redskins
The Vikings are for real. They enter this game with a 4-1 record and they are playing sound football in all areas of the game. The same cannot be said of the Redskins.
The Redskins defense has been bad. Football Outsiders has them ranked 24th in their DVOA and they are 31st in opposing passing yards.
Washington is stronger in rush defense, which will aid them in this game, but it isn't like they will be able to completely shut down Adrian Peterson; Christian Ponder has also turned this passing game into a legitimate and supremely efficient weapon.
Robert Griffin III has certainly sparked life into the Redskins offense, but the Vikings will bring the ninth-ranked DVOA into this one.
The surprise Vikings will continue to impress.
Prediction: Vikings 24, Redskins 20