The meat of the NFL season is now upon us which means that injuries are beginning to take their toll across the league.
While bumps and bruises are inevitable this time of year, some teams have it much worse than others.
Whether it be a key man or a plethora of players, these teams just aren't the same without certain personalities in the huddle.
Let's find out who's hurting the most after NFL Week 5.
The Pittsburgh Steelers are getting younger on defense and the injury bug was infectious in Week 5.
In fact, Polamalu is out. It looks like a career of hard-hitting action is beginning to take a toll on the future Hall of Famer.
Polamalu re-aggravated a calf injury and Woodley hurt his hamstring against the Philadelphia Eagles in Week 5.
For a 2-2 Steelers team who appear to be slipping, their time as a dominant NFL franchise may be up.
With three of their next four games on the road, we'll know just what the Steelers are made of after the conclusion of their game against the New York Giants in Week 9.
Right now, it looks like they need to start rebuilding.
Don't look now, but the St. Louis Rams are 3-2.
Unfortunately for them, they lost Mario Haggan and Quintin Mikell on defense and Brit Miller and Danny Amendola on offense.
Haggan, Mikell and Miller are questionable for Week 6, but Amendola is gone until November with a collarbone injury, which almost killed him.
Thankfully he'll be just fine, but the Rams offense will hurt without him. He missed all but Week 1 in 2011 and is quarteback Sam Bradford's go-to-guy.
Week 6 will be interesting to see how Bradford performs without Amendola and Miller, who plays the lost art of fullback and blocks for the franchise quarterback.
If Bradford doesn't feel comfortable in the pocket and loses confidence in his relatively untested receivers, it may turn into another ugly season for the Rams.
Expect to see just how far the Rams have come since Jeff Fisher has taken over after Week 6.
If they look unscathed by the rash of injuries, they're well on their way to prominence. If not, they'll still have some maturing to do. Becoming fearless is priceless in the NFL.
What is the worst thing for a team coming off the worst overall record in the NFL the previous season?
The Indianapolis Colts are hurting from top to bottom right now. The list only grew in Week 5 when defensive end Robert Mathis and defensive tackle Fili Moala both left the game and did not return with knee sprains.
Thanks to the consolation prize of being the NFL's worst last year, rookie quarterback Andrew Luck has the team at 2-2. The future holds promises of being great, but they are hobbled at the moment.
While they are definitely getting better with each and every game, no team can withstand the amount of injuries the Colts have this season already.
The Colts may be fun to watch, but diehard fans have to be watching with one eye open as they don't want to witness who is injured next, which seems inevitable at the moment.
The concussion is now the most talked about injury in the history of sports and possibly the world.
As the true definition of the injury continues to grow, the precaution for athletes returning to the field after being concussed is the No. 1 concern right now.
In Week 5, the worst fear for Washington Redskins fans was realized, as franchise quarterback Robert Griffin III suffered the first concussion of his NFL career.
Now, the waiting game begins. When will he return? Who knows.
If the Redskins are smart, Griffin III will sit in Week 6. Yes, everyone wants to see him play, but longer than just Week 6.
There's too much risk in rushing him back too soon. The Redskins are currently undergoing a rebuilding year and he is their future. They aren't supposed to win this season. What they don't want to do is lose RG3 for good.
Making sure he's 100 percent before he steps back onto an NFL field on Sundays is top priority in Washington right now. Don't expect him to play in Week 6.
No, Green Bay Packers quarterback Aaron Rodgers is not hurt, but many of his teammates are.
The Pack lost B.J. Raji, Jermichael Finley and Cedric Benson in Week 5 alone.
Benson needs foot surgery after his injury and could miss the rest of the season. Raji left the game on a cart after an ankle injury and Finley says he'll be back in Week 6 against the Houston Texans, but that is awfully optimistic right now.
Things just aren't clicking in Green Bay this year like they were last year and they face the dangerous Texans next, which could easily place them at 2-4.
While a team of their caliber isn't to be counted out just yet, things are starting to look dire for the Packers.
Just when do fans hit the panic button?