Baltimore Ravens safety Ed Reed is impossible to game-plan for because he knows your tendencies almost better than you do.
Reed watches so much film and studies so many players that he is rarely out of position and can often diagnose plays before they actually happen.
The fact that Reed is also physically gifted is what gives him the ability to actually make plays when he acts on this encyclopedia of knowledge. There are plenty of players who study a lot of film, but few have the speed and quickness to react in time.
Reed, on the other hand, has both and a seemingly innate ability to come up with the ball when it's in the air in his vicinity.
For a few years now, Reed has been dealing with a neck issue and other ailments that held him back against the run game. This year, however, he looks as if he has finally gotten healthy, and he is back to blowing up everything that moves in a different color jersey.
To game-plan for Reed, you would almost have to change your whole playbook, all of your tendencies, and maybe even bring in some new players.
Even then, there is still a good chance that you wouldn't fool him, and instead, he would end up making you pay for trying to attack him.