While it is too early to give up on fantasy players that aren't performing to expectations, owners with Jamaal Charles, Chris Johnson or Shonn Greene may be looking for an option to take some pressure off the rest of their roster.
Owners that hesitated on grabbing Andre Brown of the New York Giants are kicking themselves right now...or should be, at least. They missed out on his 24-point showing on Thursday.
There could still be time to submit a waiver claim for next week, though. He's currently owned in under half of the leagues on both NFL.com and ESPN.com.
That figure will skyrocket on Wednesday.
Nevertheless, there could still be time to grab one of the following players. A few will offer short-term help but one could find a permanent spot as a starter on your roster.
Mikel Leshoure, RB, Detroit Lions
This waiver-wire addition could have a long-term impact on many rosters. The Lions need to mount some kind of consistent ground attack and Kevin Smith isn't likely to be the back to provide it.
Leshoure is back from his two-game suspension and has a favorable matchup against the Titans' defense. It is a gamble playing him on Sunday without any hints from the Lions on how they plan to use their backs, but no less of a risk than playing Johnson or Charles.
Given that Smith is seen as more of a third-down back, it is reasonable to assume that Leshoure will get most of the carries for a Lions offense that needs a running game to try to get their offense clicking.
Head coach Jim Schwartz was very coy during his press conference on Friday, simply stating that he expects all of his players to make a significant contribution.
But CBS Sports is reporting that Leshoure will have a big role in the offense.
To put it simply, if Leshoure is available in your league get him. Drop your third wide receiver or running back if you have to. Drop your backup quarterback unless you drafted too early. Go with one defense or kicker...whatever you have to do. Get him.
Daryl Richardson, RB, St. Louis Rams
You might be too late on this pickup, too, but Richardson is currently owned in under 24 percent of the leagues on NFL.com.
Richardson isn't likely going to have long-term fantasy impact this season but starter Steven Jackson was out all week with his groin injury. He's listed as questionable for Chicago on the team's injury report but that could be a bit optimistic.
Jackson is a tough old-school runner and may play on Sunday. It's been said he wears a Superman shirt under his pads but I have it on good authority that Superman actually sleeps in a Jackson jersey.
Fans will have a good idea once the active rosters are released but snagging Richardson now would be a good approach. The Rams play in the early game so there will still be time to adjust rosters.
Leonard Hankerson, WR, Washington Redskins
Pierre Garcon is listed as doubtful on Sunday with a foot injury. Hankerson is expected to step in and fill the X-receiver role. This is significant, as Robert Griffin's primary read on most pass plays is his X.
Hankerson should get plenty of looks against a Bengals defense that has been surrendering yards and points through the air this season. Mark Maske of the Washington Post states he "could have a significant role at wide receiver for the Washington Redskins in Sunday’s home opener at FedEx Field against the Cincinnati Bengals."
Hankerson led the team with 68 yards, but all of those came on one long touchdown reception. He had one other catch and was targeted three times.
Josh Morgan had five receptions on five targets for 50 yards last week. He's another viable option for the Redskins' offense.
Darin Pike is a writer for Bleacher Report's Breaking News Team and a Featured Columnist covering the NFL and Seattle Seahawks.