One game down, one running back to eclipse the 100-yard mark in the books.

The Cowboys' DeMarco Murray became the first 100-yard rusher of the 2012 season Wednesday night, picking up 131 yards on 20 carries against the defending Super Bowl Champions and their division rival, the New York Giants.

Murray might be the first, but he won't be the only running back to eclipse the century mark on the ground as the season's opening week marches on.

Who is going to join him?

LeSean McCoy, Philadelphia Eagles

One of the most explosive running backs in the game today, LeSean McCoy stands to have a field day against an overmatched Browns defense that was among the worst against the run in 2011, allowing 147 yards per game on the ground.

McCoy has never faced the Browns before, and he'll be off to the races on Sunday afternoon.

Philadelphia figures to get out to an early lead against the Browns, and in an effort to keep quarterback Michael Vick from taking unnecessary hits, Eagles coach Andy Reid will feed the Browns a heavy dose of McCoy all day long.

Matt Forte, Chicago Bears

The first game Matt Forte ever played in the NFL was against the Indianapolis Colts, and in the 2008 season opener, he racked up 123 yards and a touchdown on the ground against a much better Colts defense than what he'll be facing this weekend.

Forte will best his 2008 numbers in this one and could come close to the 150-yard mark, given the fact that Chicago will be looking to eat as much clock as it can with a big second half lead.

Darren McFadden, Oakland Raiders

The Raiders take on a more talented Chargers team in one of the two Monday night games, and they may not win the game when it's all said and done.

Injured for much of 2011, McFadden hasn't faced San Diego since Week 12 of the 2010 season, when he carried the ball 18 times for 97 yards.

He'll wind up with about the same number of carries, but he'll break off a few long runs that push his yardage north of 100 yards on the night.