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How they fared last week
The first two fixtures were a bit tough for these two clubs.
Southampton put up an incredible fight against the defending Premier League champions, coming from 1-0 down to take a 2-1 lead over City. Unfortunately, they lost it 3-2 from there and have no points to show for it.
Meanwhile, Wigan started off as badly as possible against the defending European champions, falling 2-0 behind before 10 minutes passed. They settled down from there, but the scoreline never changed.
Will Southampton put on a show for their loyal supporters?
How will Wigan respond to the loss of Victor Moses?
I'm seeing a draw here.
It's easy to overreact to Southampton's success against City last week and see them as a bottom-table world-beater, but they still haven't proven themselves to any extent.
Wigan will be missing Victor Moses, who was influential against Chelsea (and is now on Chelsea), but I see them having enough to take a point. 1-1 draw.