The 36-year-old missed 20 games due to a high ankle sprain he suffered in the March 20 loss to the Atlanta Hawks and was sidelined again by the injury just days after his return. The news came as the Lakers were fighting to keep themselves out of the play-in tournament a season after claiming the NBA title.
James is averaging 25.0 points, 7.9 rebounds and 7.8 assists through 43 games this season.
While the four-time MVP is sidelined, Anthony Davis will be charged with leading the offense now that he is healthy, and Kyle Kuzma and Kentavious Caldwell-Pope should be able to help keep the team afloat.
However, it's likely that any deep run into the postseason will depend on James being at the forefront for the Lakers.