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If Walcott and Gervinho are too take full advantage of the problems they pose the Spurs back four, then Robin van Persie will need to turn provider.
The Dutchman can enjoy great success if he drops into the space between midfield and the forward line. He has the creative skill to thread the necessary passes to match Walcott's runs and Gervinho's movement.
Arsenal's top goalscorer won't win many balls with his back to the powerful combination of King and Kaboul.
Arsenal must avoid allowing van Persie to become an isolated figure up front, struggling to win goal kicks and hopeful passes.
The classy forward has the craft and guile to expose the gaps in the Spurs defense, if he can get into space.
He needs to operate in a manner similar to his style in the 2008/09 season, when van Persie assumed the creative mantle, during the prolonged injury absence of Cesc Fabregas.
It is a measure of how far Arsenal have fallen that they enter this particular North London derby as significant underdogs.
For the first time during Wenger's storied tenure, Spurs are firm favourites. Another heavy defeat will not be acceptable. The derby demands at least a resolute and committed performance from the Gunners.
Their defensive ineptitude is still a major concern, but if Arsenal combine their scoring potential with a smart approach, they can put Spurs on the back foot early and seal a hugely significant win.