With only 10 teams playing in the Premier League this weekend due to FA Cup sixth-round clashes, there is potential for the clubs involved to make headway at both the bottom and the top of the table.
A bottom-of-the-table clash between Cardiff and Fulham could see either of those sides condemned to inevitable relegation while Chelsea could increase their lead at the league's summit with a win over Tottenham.
Elsewhere, the likes of Crystal Palace, Norwich, Stoke and West Brom will all be looking to pick up points in a bid to move further away from the bottom three.
This weekend's results could see a lot of chopping and changing in the league table, especially for those flirting with relegation.
Read on for full predictions and previews of the games to watch in Week 29.
|March 8||12.45pm GMT, 7.45am ET||West Brom v Man Utd||1-3|
|March 8||3pm GMT, 10am ET||Cardiff v Fulham||1-0|
|March 8||3pm GMT, 10am ET||Crystal Palace v Southampton||2-1|
|March 8||3pm GMT, 10am ET||Norwich v Stoke||0-1|
|March 8||5.30pm GMT, 12.30pm ET||Chelsea v Tottenham||2-2|
Cardiff vs. Fulham
A huge game for both sides as the bottom two go head-to-head as they fight to stay in the Premier League for another season.
The likelihood is that, no matter the result, both of these teams may well end up playing their football in the Championship next season, but a win could be the catalyst for a miraculous escape.
Despite the fact that a draw would not be helpful for either side, expect a cagey encounter as each will be looking to avoid what could be a fatal loss.
But even if the quality of football is unlikely to be the highest, the pressure involved in encounters such as this always produce explosive, incredibly watch-able entertainment.
Will Cardiff and Fulham both be relegated?
Neither side comes into the game with anything even vaguely related to a good run of form.
Fulham have picked up only two points from their last eight league games, despite the introduction of new manager Felix Magath in February.
Similarly, Ole Gunnar Solskjaer's eight-game tenure at Cardiff has seen them pick up only one win and one draw since early January.
A defeat for either side would effectively end any chances staying up, although Magath refutes this hypothesis.
The home advantage may well be the telling factor for Cardiff, although in a game such as this anything could happen.
Prediction: Cardiff 1-0 Fulham
Chelsea vs. Tottenham
Certainly the highest-profile fixture of the weekend and a London derby that rarely disappoints, there is very little love lost between these two teams.
With Liverpool, Arsenal and Manchester City all not playing this weekend, Chelsea have a great opportunity to extend their four-point lead at the top of the league, especially as the talismanic Eden Hazard has declared himself fit.
Meanwhile, fifth-placed Tottenham will be hoping to close in on the final Champions League spot which has eluded them regularly in the last few seasons.
Chelsea are unbeaten in the league at home this season so a Tottenham win seems unlikely, but do not be surprised if Spurs can claim a point.
They have the best away record in the Premier League this season and in-form striker Emmanuel Adebayor has scored seven goals in his last six league appearances away from home, according to Eurosport.
Prediction: Chelsea 2-2 Tottenham
West Brom vs. Manchester United
Back in September, West Brom travelled to Old Trafford and came away with a 2-1 win. It was an early sign of what United's season would turn out to be.
David Moyes' side will travel to the Hawthorns to exact revenge and in the hope that they can salvage something from this season.
Manchester City's Capital One Cup victory last weekend means sixth place in the Premier League now qualifies for the Europa League and United would move into that spot with a win.
West Brom will also be looking for vital points as they currently sit in 17th on the precipice of the relegation zone.
Prediction: West Brom 1-3 Man United