The Premier League weekend begins with the biggest game of the programme on Saturday.
League leaders Arsenal travel to Liverpool for the lunchtime kick-off, hoping to extend their two-point advantage at the top of the table.
But Luis Suarez will have a point to prove to the Gunners, who bid for the Liverpool striker during the summer transfer window.
Manchester City are at Norwich City, while Chelsea play host to Newcastle United.
On Sunday, Manchester United entertain bottom club Fulham, and Champions League hopefuls Tottenham and Everton meet at White Hart Lane.
Here's the team news for the weekend games.
Liverpool vs. Arsenal
Liverpool midfielder Joe Allen is pushing for a recall, but Mamadou Sakho, Jose Enrique and Daniel Agger are still out.
Arsenal midfielder Jack Wilshere is expected to return, but Aaron Ramsey, Abou Diaby and Theo Walcott are all still out.
Aston Villa vs. West Ham United
Gabriel Agbonlahor faces a late fitness test, but Ron Vlaar is rated doubtful for Villa. Charles N'Zogbia and Jores Okore remain sidelined.
Winston Reid is set for his first start in 10 weeks after injury, while Mohamed Diame could also return for West Ham. Andy Carroll is suspended.
Chelsea vs. Newcastle United
Chelsea midfielder Oscar is poised to return to the starting line-up. Fernando Torres is back in training but is unlikely to be ready for the visit of Newcastle.
Loic Remy is suspended, while Papiss Cisse is doubtful with a back problem. Sammy Ameobi is also rated doubtful for the Magpies.
Crystal Palace vs. West Bromwich Albion
Joe Ledley, Tom Ince and Scott Dann will be pushing for a home debut at Selhurst Park, while Glenn Murray could start on the bench after a long-term injury.
Jonas Olsson is ruled out for West Brom, while James Morrison is rated doubtful for the game. Nicolas Anelka faces a late fitness test, but Stephane Sessegnon remains sidelined.
Norwich City vs. Manchester City
Jonny Howson and Michael Turner remain sidelined for Norwich with back and hamstring injuries, respectively.
Fernandinho, Samir Nasri and Sergio Aguero remain out, but Stevan Jovetic is pushing for a start for Manchester City. Javi Garcia could return.
Southampton vs. Stoke City
Calum Chambers is a doubt for Southampton, while Dejan Lovren and Gaston Ramirez remain in the treatment room.
Steven N'Zonzi returns for Stoke after suspension, but manager Mark Hughes may keep the same team that defeated Manchester United last weekend. Jon Walters and Marko Arnautovic will be assessed before the game. Robert Huth remains sidelined.
Sunderland vs. Hull City
Sunderland striker Steven Fletcher is out, while Lee Cattermole is doubtful. Long-term casualties Carlos Cuellar and Keiren Westwood remain out.
Hull goalkeeper Allan McGregor serves the second game of a three-match suspension, but Jake Livermore returns after being ineligible for the game against Spurs. James Chester is still out.
Swansea City vs. Cardiff City
Jonjo Shelvey is doubtful with a hamstring injury, while Michu and Jose Canas are both still out.
Cardiff will be without Mark Hudson (hamstring) and Andrew Taylor (calf).
Tottenham Hotspur vs. Everton
Andros Townsend and Mousa Dembele both return for Spurs, but striker Emmanuel Adebayor is doubtful.
Seamus Coleman and Gerard Deulofeu are back in contention, but Everton are still without Romelu Lukaku, Bryan Oviedo, Antolin Alcaraz and Lacina Traore.
Manchester United vs. Fulham
Nemanja Vidic returns to the Manchester United defence after suspension, while Jonny Evans (calf) is doubtful.
New Fulham striker Kostas Mitroglou is set for his first start, while John Heitinga will also be hoping for his debut. John Arne Riise is rated doubtful.