After a fast and frenetic UEFA Champions League Matchday, we barely have time to breathe before launching straight back into Premier League action.
With Tottenham Hotspur vs. Manchester United, Manchester City vs. Swansea and Chelsea vs. Southampton on the horizon, let's take a look at the latest injury news.
Aston Villa vs. Sunderland
Aston Villa will hope to end their left-back troubles by welcoming back Antonio Luna following a hamstring injury, while Fabian Delph, Andi Weimann and Gabby Agbonlahor should re-enter the side if fit enough.
Sunderland have just one injury to Keiran Westwood to concern themselves with, and welcome back Andrea Dossena and Lee Cattermole from suspension. Wes Brown's red card last week has been rescinded and he will be in the squad.
Cardiff City vs. Arsenal
Malky Mackay has no fresh injuries to contend with as he attempts to end a sequence of one win from the last six matches.
Arsenal will be without the usual suspects, but Kieran Gibbs returns to the squad after illness.
|Aston Villa||Questionable||Antonio Luna||Hamstring|
Everton vs. Stoke City
Everton will be without star man Leighton Baines for the visit of Stoke City as the defender recovers from a broken metatarsal. John Stones or Bryan Oviedo are in line to replace him at left-back.
Stoke will be without defender Robert Huth (knee) and Marko Arnautovic (hamstring), but Stephen Ireland is expected to be fit after a shin problem. Marc Wilson and Kenwyne Jones remain sidelined.
Norwich City vs. Crystal Palace
Norwich take on Palace in a battle of the walking dead, as both sides have a sizable injury list to contend with.
The Canaries' biggest misses are Anthony Pilkington and Robert Snodgrass, but they are hopeful that Ricky van Wolfswinkel will be available. Palace must do without Yannick Bolasie (suspended) and Marouane Chamakh.
Nathan Redmond becomes a strong fantasy play for the foreseeable future.
West Ham United vs. Fulham
The game between West Ham and Fulham on Saturday sees two teams that are desperate for points lock horns.
Sam Allardyce will be without his entire striking corps once again in addition to left-back Razvan Rat, while Martin Jol loses Sascha Riether to suspension and Brede Hangeland is doubtful with a sciatic nerve problem. Dimitar Berbatov is also rated as doubtful after illness.
|Alexander Tettey||High Ankle Sprain|
|Ricky van Wolfswinkel||Foot|
Newcastle United vs. West Bromwich Albion
Newcastle welcome back in-form defender Mathieu Debuchy from suspension, while Steven Taylor could also return from a hamstring problem.
West Brom have a chunk of players under the microscope, but Billy Jones and Liam Ridgewell retain a strong chance of re-entering the starting XI.
|West Ham||Questionable||Razvan Rat||Hamstring|
|Ricardo Vaz Te||Shoulder|
|Brede Hangeland||Sciatic Nerve|
Tottenham Hotspur vs. Manchester United
Tottenham's Emmanuel Adebayor could be out of with a groin injury after making his first cameo of the season at Manchester City on Sunday.
United have no fresh injuries, but Phil Jones could return to the midfield. Robin van Persie and Nemanja Vidic are expected to return.
|West Brom||Questionable||Scott Sinclair||Hamstring|
Hull City vs. Liverpool
Hull will be without defender Paul McShane, but Curtis Davies is expected to return. James Chester could be named among the substitutes after two months on the sidelines.
Liverpool will be without Jose Enrique until February following a knee injury, with Iago Aspas not quite ready to return. Jon Flanagan is expected to continue at full-back and Daniel Sturridge may return to the starting line-up.
|Man Utd||Questionable||Robin van Persie||Groin|
Manchester City vs. Swansea City
Manuel Pellegrini could have both Vincent Kompany and Matija Nastasic ready for this weekend's clash with Swansea, but isn't likely to risk his captain just yet. David Silva and Jack Rodwell remain out.
Swansea will be without Wilfried Bony for several weeks due to a hamstring injury, while Angel Rangel (calf) misses the trip to the Etihad Stadium. Wayne Routledge is set to return from a calf problem, but Michu is still sidelined.
|Hull||Questionable||Robbie Brady||Gilmores Groin|
Chelsea vs. Southampton
Chelsea manager Jose Mourinho will be without striker Samuel Eto'o and defender David Luiz for the visit of the Saints.
Southampton have picked up a flurry of injuries in the last week, with Luke Shaw in particular a worry. Dejan Lovren should return.
|Man City||Questionable||Matija Nastasic||Knock|
We will update with team news as and when we receive it.